The University of Siena PhD Course in
Genetics, Oncology and Clinical Medicine


Lab Meeting Programme
PROGRESS REPORT SCHEDULE, ACADEMIC YEAR 2018-2019

February 26th, 2019 at 1pm, Centro Didattico Le Scotte, room 9
- Nicolì Vanessa (tutor Prof. Migliore)
Title: "study on epigenetic modifications in human placentas and buccal mucosa cells of newborns" 

- Gallo Roberta (Tutor Prof. Coppedè)
Title: " Methylation analysis in girls with Autism Spectrum Disorders (ASD)

- Dapporto Francesca (Tutor Dr. Chiariello)
Title: "Role of MAPK15 protein in human tumors"

March 7th, 2019 at 1pm, Centro Didattico Le Scotte, room 6
- Bergantini Laura (Tutor Prof. Bargagli) 
Title: "Idiopathic Pulmonary Fibrosis, serum proteomic analysis before and after nintedanib therapy"

- Fulco Beniamino (Tutor Prof. Giordano)
Title: "Preventive and antiproliferative effects of tomato extracts on colorectal cancer"

- Fui Annalisa (Tutor Prof. Bargagli)
Title: "Rituximab Therapy in Interstitial Lung Disease (ILD) associated with Rheumatoid arthritis"

April 19th, 2019 at 1pm, Centro Didattico Le Scotte, room 6
- Beltrami Matteo (Tutor prof. Nuti )
Title: "Multimodality imaging in cardiomyopathies: correlation with genetic and pathological substrates, functional capacity, prognostic stratification and virtual modeling"

- Anichini Giulia (Tutor Prof. Stecca )
Title: "The role of the Hedgehog pathway in cholangiocarcinoma"

- Ferrigno Ilaria (Tutor Prof. Bocchia)
Title: "Prognostic role of Isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) mutations in Acute Myeloid Leukemia"

May 17th, 2019 at 1pm, Centro Didattico Le Scotte, room A
- Dell'Aquila Milena (Tutor Prof. Giordano)
Title: "Phosphoproteomic screening reveals the multiple functions of cdk9 in dna damage response "

- D'Angelo Costantino (Tutor Prof. Giordano)
Title: "Evaluation of anti-proliferative and antioxidant potential of tomatoes extracts against melanoma"

- Bonetti Justine (Tutor Dr. Conticello)
Title: "Therapeutic potential of S-nitrosothiols in the prevention of atherosclerosis: Modulation of monocytes and smooth muscle cells metaplasia into foam cells"


May 21th, 2019 at 1pm, Centro Didattico Le Scotte, room 13
- Tarantino Danilo (Tutor Dr. Conticello)
Title: "The weight of APOBEC mutations in cancer development"

- Martignano Filippo (Tutor Dr. Conticello)
Title: "Third generation sequencing: liquid biopsy applications"

- Cannito Sara (Tutor Prof. Maio)
Title: 

- Farhad Jahanfar (Tutor Prof. Arcangeli)
Title: "High-throughput screening of analgesic compounds"


June 19th, 2019 at 1pm, Centro Didattico Le Scotte, room 11
- Lembo Gaia (Tutor Dr. Conticello)
Title: "Drugging the mutators: Design of inhibitors of APOBECs"

- Palmieri Maria (Tutor Dr. Frullanti)
Title: "Cell free-DNA pinpoints specific clonal expansion at disease in solid cancers"


June 25th, 2019 at 1:30pm, Centro Didattico Le Scotte, room 14
- Croci Susanna (Tutor Dr. Meloni)
Title: 

-Lorenzetti Flaminia (Tutor Prof.ssa Mari)
Title: 




PROGRESS REPORT SCHEDULE, ACADEMIC YEAR 2017-2018

11th January 2018 at 15.00 - Centro Didattico Le Scotte, Room 6

- Barsotti Simone (Mosca)
Title: "Effects of hydroxychoroquine supplementation on mesenchymal stromal cells in an animal model of Systemic Lupus Erythematosus (SLE): preliminary results and further prospective"

- De Palma Anna (Galeazzi-Fioravanti)
Title: "Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway"

- Beltrami Matteo (Nuti)
Title: "Multimodality imaging in cardiomyopathies: correlation with genetic and pathological substrates, functional capacity, prognostic stratification and virtual modelling"



22th January 2018 at 15.00 - Centro Didattico Le Scotte, Room 6

- Tubita Alessandro (Dello Sbarba)
Title: "Targeting the Mitogen-Activated Protein Kinase ERK5 in human melanoma" 

- Lamberti Arianna (Fimiani)
Title: "Molecular evolution of cutaneous cd30 positive lymphoproliferative disorders: pathogenetic and clinical implications"

- Anichini Giulia (Stecca)
Title: "Deconstructing the molecular program induced by SOX2 and GLI1"



5th February 2018 at 15.00 - Centro Didattico Le Scotte, Room 6

- Montini Marco (Conticello)
Title: "Assaying the order of events in cells through CRISPR/Cas9"

- Chieca Martina (Conticello)
Title: "Dimerization of APOBEC1 is dispensable for RNA editing"

- Di Giorgio Salvatore (Conticello)
Title: "APOBEC1-dependent RNA editing, a bioinformatics approach"

- Donati Francesco (Conticello)
Title: "APOBEC1 mutants to assess RNA and DNA editing component in cancer"



12th February 2018 at 15.00 - Centro Didattico Le Scotte, Room 6

- Iorio Jessica (Arcangeli)
Title: "Functional relationships between ion channels and pH-regulating mechaninsms in colorectal cancer"

- Antonuzzo Lorenzo (Arcangeli)
Title: "Expression and prognostic significance of hERG1 in Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs)"

- Cesari Daniele (Giordano A)
Title: "PRMT5 as two-in-one strategy for mesothelioma treatment"

- Cosi Irene (De Angioletti)
Title: "Transcriptional regulation and oncogenic effects of the genes deregulated by the prostate-specific expression of ETV4"



21th February 2018 at 15.00 - Centro Didattico Le Scotte, Room 6

- Grassi Susanna (Galimberti)
Title: "Pharmacogenomic, epigenetic, proteomic, and immunological variables as possible predictive markers of response and toxicity in patients affected by chronic myeloid leukemia (CML) receiving tyrosin kinase inhibitors (TKIs)"

- Antonuzzo Lorenzo (Arcangeli)
Title: "Expression and prognostic significance of hERG1 in Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs)"

- Brogi Alice (Santini)
Title: "Mechanisms of resistance to hypomethylating agents in MDS/AML syndromes"

- Poteti Martina (Dello Sbarba)
Title: "The metabolic profile of Chronic Myeloid Leukaemia (CML) stem cell subsets as a target to suppress minimal residual disease resistant to tyrosine kinase inhibitors"

- Lorenzetti Flaminia Clelia (Renieri)
Title: 



9th March 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Corbizi Fattori Giuditta (Vannucchi)
Title: "Exploiting mutated CALR for diagnostic, prognostic and therapeutic purposes in MPN"

- Fanelli Tiziana (Vannucchi)
Title: "Clonal heterogeneity and clonal progression in the leukemic transformation of chronic myeloproliferative neoplasms"

- Materozzi Maria (Nuti)
Title: "Molecular biology of Paget’s Disease of Bone: role of p62 and novel genes"

- Croci Susanna (Giannotti)
Title: "cell therapy and scaffolds in chondral and osteochondral injuries" / "FOXG1 gene therapy using CRiSPR/Cas9 technology and AVV9 system i iPSCs-derived neurons"



22th March 2018 or 4th April 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Stoccoro Andrea (Migliore)
Title: "Mitochondrial DNA methylation in neurodegenerative diseases"

- Nicolì Vanessa (Migliore)
Title: "Environmental factors of prenatal risk: a study of epigenetic modification in human placentas and buccal mucosa cells of newborns"

- Gallo Roberta (Migliore)
Title: "Methylation analysis in girls with Autistic Spectrum Disorders (ASD)"

- Guarnieri Giulia (Vannelli)
Title: "Study of the genetic and epigenetic mechanisms regulating neurogenesis in human cholinergic neurons"



11th April 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Cannito Sara (Maio)
Title: "Modeling of cancer immune phenotype by new epigenetic drugs: a strategy to improve efficacy of immunotherapy"

- Monterisi Santa (Maio)
Title: "Immune-remodeling activity of epigenetic drugs as base for novel combinatorial immunotherapy clinical trials for cancer patients"

- D'Angelo Costantino (Giordano A)
Title:

- Fulco Beniamino (Giordano A)
Title: "The impact of genetic variation on nutrients metabolism can help to identify risk for cancer progression"



23th April 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Ferrigno Ilaria (Bocchia)
Title: "Prognostic role of isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) mutations in Acute Myeloid Leukemia"

- Fui Annalisa (Rottoli)
Title: "Biomarkers analysis, clinical-radiological characterization and response to biologic therapy of patients with Interstitial lung diseases with Autoimmune Disorders of Connective Tissue"

- Bergantini Laura (Rottoli)
Title:

- Valentini Maria Lucia (Rottoli)
Title:



11th May 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Mori Elena (Di Leo)
Title: "Serum metabolomic profiles (smps) for discriminating early from metastatic disease and predicting relapse in patients (pts) with crc"

- Laera Letizia (Di Leo)
Title: "Exploratory investigation of serum metabolomics as predictive biomarkers of response to checkpoint inhibitors in patients with advanced non-small-cell lung cancer (NSCLC)"

- Vitale Stefania (Di Leo)
Title:

- Palmieri Maria (Frullanti)
Title: "Identification of genetic bases of individual predisposition to lung cancer in non-smokers"



16th May 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Finizola Francesco (Laghi Pasini)
Title: "Systemic inflammation as a novel QT-prolonging risk factor"

- Leonardi Margherita (Chiariello)
Title: "Screening of a library of activated Kinases  identifies the IKBKE Oncogene as a positive regulator of the Autophagic process"

- Dapporto Francesca (Chiariello)
Title:

- Tognetti Linda (Fimiani)
Title: "Clinical and laboratory characterization of patients with cutaneous sclerosing disorders and response to UVA-1 and extracorporeal photochemotherapy: in vivo and in vitro skin models"



31th May 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Astarita Carlo (Giordano A)
Title: "Hormone imbalance causes aberrant PAI-2 and pRb2/p130 function promoting eye disease"

- Menicacci Beatrice (Del Rosso)
Title: "Chronic treatment with resveratrol and olive oil phenols on MRC5 fibroblast SASP: inhibition of  pro-tumoral microenvironment"

- Altieri Angela (Giordano A)
Title: "Development of new technologies for identification of a novel proteins involved in the DNA damage response (DDR)"

- Dell'Aquila Milena (Giordano A)
Title: "Identification of hnRNPD protein interactions in response to DNA damaging agents"



11th June 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Gelli Elisa (Ariani)
Title: "Evidences of constitutive promoter hypermethylation in Retinoblastoma"

- Daga Sergio (Mari)
Title: "CRiSPR/Cas9 gene therapy on urine-derived-podocytes-like cells: a new perspective in treatment of ATS"

- Catania Lorenza Maria (Renieri)
Title: "Disturbance of GABA-ergic transmission in FOXG1 neurons"

- Paganini Irene (Papi)
Title: "Identification of novel schwannomatosis genes through exome sequencing"



June or July 2018 at 15.00 - Centro Didattico Le Scotte, Room 

- Taratino Danilo (Conticello)
Title: "Evidences of constitutive promoter hypermethylation in Retinoblastoma"

- Martignano Filippo (Conticello)
Title: 

- Lembo Gaia (Conticello)
Title: 





PROGRESS REPORT SCHEDULE, ACADEMIC YEAR 2016-2017


20th July 2017 at 14.00 - Centro Didattico Le Scotte, Room 9

- Tubita Alessandro (Dello Sbarba)
Title: "Targeting the Mitogen Activated-Protein Kinase ERK5 in human melanoma"

- Poteti Martina (Dello Sbarba)
Title: "The metabolic profile of Chronic Myeloid Leukaemia stem cell subsets as a target to suppress treatment-resistant minimal residual disease"

Antonuzzo Lorenzo (Arcangeli)
Title: "Expression and prognostic significance of hERG1 in gastroenteropancreatic neuroendocrine neoplasms"



12th July 2017 at 14.00 - Centro Didattico Le Scotte, Room 6

Stoccoro Andrea (Migliore)
Title: "Mitochondrial DNA methylation in neurodegenerative diseases"

Guarnieri Giulia (Vannelli)
Title: "Study of genetic and epigenetic mechanisms regulating neurogenesis in human cholinergic neurons"

Gelli Elisa (Ariani)
Title: "Hereditary breast and ovarian cancer: characterization of new BRCA1/BRCA2 variants inducing  splicing pattern perturbations"

Paganini Irene (Papi)
Title: "Identification of novel schwannomatosis genes through exome sequencing"



5th July 2017 at 14.30 - Centro Didattico Le Scotte, Room 13

- Iorio Jessica (Arcangeli)
Title: "Functional relationships between K+ channels and pH-regulating mechanisms in colorectal cancer"

- Materozzi Maria (Nuti)
Title: "Molecular biology of Paget’s Disease of Bone: role of p62 and novel genes"

Lamberti Arianna (Fimiani)
Title: "Genetic and molecular aspects of  cutaneous anaplastic T-cell lymphoma"



28th June 2017 at 14.00 - Centro Didattico Le Scotte, Room 6

Landucci Elisa (Renieri)
Title: "Modeling Rett syndrome with iPSCs-derived neurons"



14th June 2017 at 14.00 - Room within Library of Medical Biotechnologies Department - 3° Floor 2° lot

- Daga Sergio (Mari)
Title: "Urine-derived podocytes-like cells as diagnostic and therapeutic tool in Alport syndrome"

- Pinto Anna Maria (Renieri)
Title: "RNA-seq analysis of amniotic fluid Alport patient-derived podocytes reveals a generalized  disruption of extracellular matrix genes along with overexpression of inflammatory cytokines"

- Finizola Francesco (Laghi Pasini)
Title: "Systemic inflammation as a novel QT-prolonging risk factor"

Sarti Samantha (Poliseno)
Title: "Assessing the biological role of miR-204 in a zebrafish melanoma model"



12th May 2017 at 14.00 - Centro Didattico Le Scotte, Room 10

Simone Barsotti (Mosca)
Effects of hydroxychoroquine and 25-OH vitamin D supplementation on mesenchymal stromal cells and endothelial function in an animal model of Systemic Lupus Erythematosus (SLE)

- Anna De Palma (Galeazzi, Fioravanti)
MicroRNAs expression after Cyclic Hydrostatic Pressure in human normal and osteoarthritic chondrocyte cultures

- Susanna Grassi (Galimberti)
Pharmacogenomic, epigenetic and proteomic variables as possible predictive markers of response and toxicity in patients affected by chronic myeloid leukemia (CML) receiving tyrosin kinase inhibitors (TKIs).



18th April 2017 at 14.00 - Centro Didattico Le Scotte, Room 6

- Altieri Angela (Giordano A)
Developement of new thecnologies for identification of Novel proteins involved in DNA damage response


6th April 2017 at 14.00 - Centro Didattico Le Scotte, Room 10

- Giacobini Gianluca (Maio)
Title: Identification of immune correlates of clinical activity and/or disease outcome in melanoma patients undergoing targeted therapy

- Lofiego Maria Fortunata (Maio)
Title: A new human cell-based vaccine for cancer therapy: pre-clinical characterization

- Tognetti Linda (Fimiani)
Title: Clinical and laboratory characterization of patients with sclerosing cutaneous disorders and response to UVA-1 phototherapy and extracorporeal photochemotherapy: in vitro and in vivo skin models



31st March 2017 at 14.00 - Centro Didattico Le Scotte, Room 6

- Mori Elena (Dello Sbarba - Di Leo)
Title to be defined

- Vitale Stefania (Dello Sbarba - Di Leo)
Title to be defined

- Laera Letizia (Francini - Di Leo)
Title to be defined

- Cesari Daniele (Giordano)
Title: "PRMT5 inhibition as multifaceted strategy in cancer treatment"

- Altieri Angela  (Giordano)
Title: "DEVELOPEMENT OF NEW TECHNOLOGIES FOR IDENTIFICATION OF NOVEL PROTEINS INVOLVED IN DNA DAMAGE RESPONSE"



22th March 2017 at 14.00 - 

- Corbizi Fattori Giuditta (Vannucchi)
Title: "Exploiting mutated calreticulin for diagnostic prognostic and therapeutic purposes in chronic myeloproliferative neoplasms"

- Fanelli Tiziana (Vannucchi)
Title: "Clonal heterogeneity and clonal progression in the leukemic transformation of chronic myeloproliferative neoplasms"

- Brogi Alice (Santini)
Title: "Mechanisms of resistance to hypomethylating agents in MDS/AML syndromes"

- Cencini Emanuele (Bocchia)
Title: "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with non-Hodgkin lymphomas"

- Candi Veronica (Bocchia)
Title: "Next Generation flow cytometry for detecting minimal residual disease in multiple myeloma patients"



27th February 2017 at 14.00 - Seminar Room Building 27, Core Research Laboratory ITT, Viale Pieraccini, 6 - Firenze

- Montini Marco (S. Conticello)
Title: "Assaying the order of events in cell throught CRISPR/Cas9"

- Chieca Martina (S.Conticello)
Title: "Impact of APOBEC1 mediated RNA editing in Retinoblastoma tumor suppressor protein"

- Di Giorgio Salvatore (S.Conticello)
Title: "Apobec dependent una editing, a bioinformatic approach"

- Donati Francesco (S.Conticello)
Title: "Assessing the mutagenic activity of APOBEC1 mutants" 



6th February 2017 at 14.00 - Centro Didattico Le Scotte, Room 9

- Menicacci Beatrice (M. Del Rosso)
Title: "Senescence secretory phenotype and tumor microenvironment: modulation by polyphenolic compounds"

- Leonardi Margherita (M. Chiariello)
Title: "IKBKE oncogene upregulates autophagy in breast cancer"

- Cosi Irene (M. De Angioletti)
Title: "Establishment of primary prostate cell lines from transgenic mice: a tool to study prostate specific genetic alterations"

- Mancuso Pietro (A. Giordano)
Title: "Role of TDG in DNA demethylation and transcriptional regulation in melanoma"



30th November 2016 at 13:00 - Centro Didattico Le Scotte, Room 6

- Astarita Carlo (A. Giordano)
Title: "Hormone Imbalance Promotes Eye Disease Through Chronic Cellular Stress"

- Delaram Rahmani (A. Giordano)
Title: "Novel insight of Pyrvinium Pamoate anti-cancer activity: a study on mesothelioma"



PROGRESS REPORT SCHEDULE, ACADEMIC YEAR 2015-2016

Date to be determined - Centro Didattico Le Scotte
- Cheleschi Sara (A. Fioravanti, M. Galeazzi)
Title: "Evaluation of a new pharmacological compound by an in vitro study on human osteoarthritic chondrocytes"

- De Palma Anna (A. Fioravanti, M. Galeazzi)
Title to be defined

- Barsotti Simone (M. Mosca)
Title to be defined

- Antonuzzo Lorenzo (A. Arcangeli)
Title: "Valutazione dell’espressione e del ruolo prognostico del canale del potassio human etere-a-go-go-related nelle neoplasie neuroendocrine del pancreas"

- Iorio Jessica (A. Arcangeli)
Title: "Functional relationships between k+ channels and pH- regulating mechaninsms in colorectal cancer"

- Montella Antonio (R. Nuti)
Title: "Three years evaluation of scleroderma patients in order to identify a disease progression index"



July 14, 2016 at 13:30 - Centro Didattico Le Scotte, Room 13

- Guarnieri Giulia (Vannelli)
Title: "Study of genetic and epigenetic mechanisms regulating neurogenesis in human cholinergic neurons"

- Menicacci Beatrice (M. Del Rosso)
Title: "Senescence secretory phenotype and tumor microenvironment: modulation by polyphenolic compounds"

- Sarti Samanta (L. Poliseno)
Title: "Assessing the biological role of miR-211 family in a zebrafish melanoma model"

- Lamberti Arianna (M. Fimiani)
Title: "Genetic and molecular aspects as possible predictive clinical evolution of Lymphomatoid Papulosis"



June 29, 2016 at 14:00 - Centro Didattico Le Scotte, Room A

- Imperatore Valentina (A. Renieri)
Title: "Massive parallel sequencing in sporadic retinoblastoma patients reveals somatic mosaicism"

- Landucci Elisa (A. Renieri)
Title: "Modeling Rett syndrome with iPSCs-derived neurons"

- Pinto Anna Maria (A. Renieri)
Title: "Molecular basis of Arteriovenous Malformations (AVMs)"

-Daga Sergio (A. Renieri)
Title: "In vitro podocyte-like cell system: a new approach to understand Alport Syndrome"



June 23, 2016 at 13:30 - Centro Didattico Le Scotte, Room 6

- Grassi Susanna (S. Galimberti)
Title: "Pharmacogenomic, epigenetic, proteomic, and immunological variables as possible predictive markers of response and toxicity in patients affected by chronic myeloid leukemia (CML) receiving tyrosin kinase inhibitors (TKIs)"

- Penon Antonella (A. Giordano)
Title: "Study of the role of various tomato cultivars in colorectal cancer development"

- Bennett David (P. Rottoli)
Title: "Research of clinical biomarkers with diagnostic and prognostic meaning in patients with interstitial lung diseases and lung transplant"

- Astarita Carlo (A. Giordano)
Title: "Hormone imbalance promotes eye disease through chronic cellular stress"



Maggio 12, 2016 at 13:00 - Centro Didattico Le Scotte, Room 14

- Montini Marco (S. Conticello)
Title: "Assaying the order of events in cells through CRISPR/Cas9"

- Tommolini Federica (E. Carnevali)
Title:  "New frontiers in genetic investigation for forensic purposes: implementation of SNPs analysis system for predicting phenotypic traits (eye color) from a biological stain"



March 30, 2016 at 14:00 - Centro Didattico Le Scotte, Room 14

- Lopomo Angela (L. Migliore)
Title: "Genetic and epigenetic biomarkers in myasthenia gravis"

- Stoccoro Andrea (L. Migliore)
Title: "Epigenetic mechanisms in Mitochondrial Diseases"

- Mori Elena (P. Dello Sbarba)
Title: "Serum metabolomic profiles for discriminating early from metastatic disease and predicting relapse in patients with colorectal cancer"

- Poteti Martina (P. Dello Sbarba)
Title: "The metabolic profile of Chronic Myeloid Leukaemia stem cell subsets as a target to suppress minimal residual disease resistant to tyrosine kinase inhibitors"

- Tubita Alessandro (P. Dello Sbarba)
Title: "Targeting the Mitogen-Activated Protein Kinase ERK5 in human melanoma"

- Vitale Stefania (P. Dello Sbarba)
Title: "Role of endocrine therapy in combination with anti-HER2 therapy and CDK4/6 inhibitors in hormone receptor positive/HER2 positive breast cancer"



March 4, 2016 at 14:00 - Centro Didattico Le Scotte, Room 13

-Chiarucci Carla (M. Maio)
Title: "Identification of immune-related biomarkers that can be predictive for clinical responses to targeted
therapies in melanoma patients"

- Fazio Carolina (M. Maio)
Title:  "Pre-clinical development of new combined epigenetic and immunotherapeutic approaches for (the treatment of ) malignant mesothelioma"

- Giacobini Gianluca (M. Maio)
Title: "Identification of immune correlates of clinical activity and/or disease outcome in melanoma patients
undergoing immunotherapy or targeted therapy"

- Lofiego Maria (M. Maio)
Title: "A new human cell-based vaccine for cancer therapy: pre-clinical characterization"



February 19, 2016 at 14:00 - Centro Didattico Le Scotte, Room 13

- Belcastro Eugenia (A. Pompella)
Title: "Inflammation and denitrosating enzymes: from the development of a cellular inflammatory model to pathological tissues"

- Delaram Rahmani (A. Giordano)
Title: "Characterization of the CISD2 mutation of Wolfram syndrome 2 in fibroblasts and iPSC derived cells"



February 10, 2016 at 14:00 - Centro Didattico Le Scotte, Room 6

-Caporaso Antonella (A. Giordano)
Title: "Characterization of p54/NONO molecular degradation mechanism"

- Iannuzzi Carmelina (A. Giordano)
Title: "Tackling malignant mesothelioma : multiple approaches are required"


January 29, 2016 at 14:00 - Centro Didattico Le Scotte, Room 6

- Mancuso Pietro (A. Giordano – A. Bellacosa)
Title: "Role of TDG in DNA demethylation and transcriptional regulation in melanoma"



January 22, 2016 at 14:00 - Centro Didattico Le Scotte, Room 6

- Aprile Lara (M. Bocchia)
Title: "Increased atherothrombotic risk and nilotinib treatment in chronic myeloid leukemia patients: a probable role for genetic predisposition and induced pro-inflammatory/pro-oxidative status"

- Cencini Emanuele (M. Bocchia)
Title: "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with non-Hodgkin lymphomas"

- Papini Giulia (M. Bocchia)
Title: "Prognostic role of the quantification of NPM1 minimal residual disease in NPM1 positive AML patients"

- Fanelli Tiziana (A. Vannucchi)
Title: "Clonal heterogeneity and clonal progression in the leukemic transformation of chronic myeloproliferative neoplasms"

- Corbizi fattori Giuditta (A. Vannucchi)
Title: "Exploiting mutated calreticulin for diagnostic, prognostic and therapeutic purposes in chronic myeloproliferative neoplasms"



PROGRESS REPORT SCHEDULE, ACADEMIC YEAR 2014-2015

June 26, 2015 - Centro Didattico Le Scotte, 13.00-14.00 – Room 4

Pinto Anna Maria (A. Renieri): "Molecular basis of Arteriovenous Malformations (AVMs)"

Giacobini Gianluca (M. Maio): "Identification of immune correlates of clinical activity and/or disease outcome in melanoma patients undergoing immunotherapy or targeted therapy"

Lofiego Maria (M. Maio): "A new human cell-based vaccine for cancer therapy: pre-clinical characterization"



June 17, 2015 - Centro Didattico Le Scotte, 12.00-13.00 – Room 13

Delaram Rahmani (A. Giordano): "The role of cell cycle regulators in human cancer"

Landucci Elisa (A. Renieri): "Modeling Rett syndrome with iPSCs-derived neurons"

Mancuso Pietro (A. Giordano – A. Bellacosa): "Role of TDG in DNA demethylation and transcriptional regulation in melanoma"

Sarti Samantha (L. Poliseno): "New approaches for the identification and the study of pseudogenes in melanoma"



June 8, 2015 - Centro Didattico Le Scotte, 14.00-15.00 – Room 6

Cencini Emanuele (M. Bocchia): "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with non-Hodgkin lymphomas"




May 19, 2015 - Centro Didattico Le Scotte, 12.00-13.30 – Room 6

Imperatore Valentina (A. Renieri): "Massive parallel sequencing in sporadic retinoblastoma patients reveals somatic mosaicism"

Lopomo Angela (L. Migliore): "Genetic and epigenetic biomarkers in myasthenia gravis"

Penon Antonella (A. Giordano): "Study of the role of various tomato cultivars in colorectal cancer development"




May 12, 2015 - Centro Didattico Le Scotte, 12.00-13.00 – Room 14

Cheleschi Sara (A. Fioravanti, M. Galeazzi): "Possible chondroprotective effect of canakinumab: an in vitro study on human osteoarthritic chondrocytes"

Chiarucci Carla (M. Maio): "Identification of immune-related biomarkers that can be predictive for clinical responses to targeted therapies in melanoma patients"

Fazio Carolina (M. Maio): "Pre-clinical development of new combined epigenetic and immunotherapeutic approaches for (the treatment of ) malignant mesothelioma"

Iannuzzi Carmelina (A. Giordano): "Dissecting the molecular mechanisms underlying mesotelioma development and progression"



May 8, 2015 - Centro Didattico Le Scotte, 12.00-13.00 – Room 14

Cutaia Ornella (M. Maio): "Recognition of melanoma associated antigens and HLA-matched melanoma cell lines by PBMCs from metastatic melanoma patients in the course of immunotherapy with immune checkpoint blockade agents"

Belcastro Eugenia (A. Pompella): "Inflammation and denitrosating enzymes: from the development of a cellular inflammatory model to pathological tissues"

Bennett David (P. Rottoli): "Research of clinical biomarkers with diagnostic and prognostic meaning in patients with interstitial lung diseases and lung transplant"

Caporaso Antonella (A. Giordano): "Identification of novel CDK9-55 kDa substrates involved in DNA damage response"



April 29, 2015 - Centro Didattico Le Scotte, 13.00-14.00 – Room 14

Ciabatti Elena (S. Galimberti): "Myelodysplastic syndromes: a multidisciplinary integrated diagnostic work-up for patients’ risk stratification"

Della Latta Veronica (M.A. Morales): "Adenosine modulation in the process of cardiopulmonary fibrosis. Bio-molecular characterization of receptor subtypes at tissue and peripheral level"

Magnotti Flora (M. Galeazzi): "Role of neutrophils activation in the pathogenesis of systemic juvenile idiopathic arthritis"

Aprile Lara (M. Bocchia): "Increased atherothrombotic risk and nilotinib treatment in chronic myeloid leukemia patients: a probable role for genetic predisposition and induced pro-inflammatory/pro-oxidative status"



April 15, 2015 - Centro Didattico Le Scotte, 13.00-14.00 – Room 14

Bianciardi Laura (F. Ariani): "Set up whole exome sequencing"

Blagojevic Jelena (M. Matucci Cerinic): "Role of pleiotrophin and midkine in systemic sclerosis"

Gentile Daniela (F. Laghi Pasini): "Expression and function of the P2X7 receptor in dermal fibroblasts from patients with Systemic Sclerosis"

Carli Linda (M. Mosca): "Urinary biomarkers in the differential diagnosis between lupus nephritis and pre-eclampsia: preliminary data"



LAB MEETING SCHEDULE ACADEMIC YEAR 2013-2014

June 17, 2014- Centro Didattico Le Scotte, 16.00-18.00

"Experimental protocol for non-invasive analysis of maternal plasma" - Imperatore Valentina (XXIX cycle, tutor: A. Renieri)

"FOXG1 impact on adult brain in congenital Rett syndrome" - Amabile Sonia (XXVII cycle, tutor: F. Mari)

"Evaluation of serum levels of some adipokines in patients with chronic inflammatory joint diseases before and after treatment with biologics" - Cheleschi Sara (XXIX cycle, tutor: A. Fioravanti, M. Galeazzi)

"Role of neutrophils activation in the pathogenesis of systemic juvenile idiopathic arthritis" - Magnotti Flora (XXVIII cycle, tutor: M. Galeazzi)

"Evaluation of the potential anticancer activity of a RB2-derived small molecule on glioblastoma cell line" - Napoliello Luca (XXVII cycle, tutor: A. Giordano)



June 5, 2014- Centro Didattico Le Scotte, 16.00-18.00

"Dissecting the molecular mechanisms underlying mesotelioma development and progression" - Iannuzzi Carmelina (XXIX cycle, tutor: A. Giordano)

"Identification of novel CDK9-55 kDa substrates involved in DNA damage response" - Caporaso Antonella (XXIX cycle, tutor: A. Giordano)

"Study of the role of mediterranean diet in colorectal cancer prevention and in a possible supporting strategy of chemiotherapy" - Penon Antonella (XXIX cycle, tutor: A. Giordano)

"Identification of immune-related biomarkers that can be predictive for clinical responses to immunomodulating agents and /or targeted therapies in melanoma and mesothelioma patients" - Carla Chiarucci (XXIX cycle, tutor: M. Maio)

"Pre-clinical development of new combined epigenetic and immunotherapeutic approaches for (the treatment of ) malignant mesothelioma" - Fazio Carolina (XXIX cycle, tutor: M. Maio)



May 22, 2014- Centro Didattico Le Scotte, 16.00-18.00

"Research of clinical biomarkers with diagnostic and prognostic meaning in patients with interstitial lung diseases and lung transplant" - Bennett David (XXIX cycle, tutor: P. Rottoli)

"Peripheral Arterial Occlusive Disease (Paod) is still an unexplained side effect in CML patients treated with Tyrosine Kinase Inhibitors: study of possible mechanisms underlining this adverse event" - Aprile Lara (XXIX cycle, tutor: M. Bocchia)

"Genetic and epigenetic biomarkers in myasthenia gravis" - Lopomo Angela (XXIX cycle, tutor: L. Migliore)

"Circulating tumor markers: predictors of incomplete cytoreduction and powerful determinants of outcome in peritoneal carcinomatosis of colorectal origin" - Cioppa Tommaso (XXIX cycle, tutor: F. Roviello)

"Urinary biomarkers in lupus nephritis: preliminary data" - Carli Linda (XXVIII cycle, tutor: M. Mosca)



May 6, 2014- Centro Didattico Le Scotte, 16.00-18.00

"Genetics and tolerance of virtual reality distraction intervention in cancer patients" - Milanese Carla (XXVII cycle, tutor: A. Giordano)

"Adenosine modulation in the process of cardiopulmonary fibrosis. Bio-molecular characterization of receptor subtypes at tissue and peripheral level" - Della Latta Veronica (XXVIII cycle, tutor: M.A. Morales)

"Expression and function of the P2X7 receptor in dermal fibroblasts from patients with Systemic Sclerosis" - Gentile Daniela (XXVIII cycle, tutor: F. Laghi Pasini)

"Identification of new oncogenes involved in the autophagic process" - Merelli Eva (XXVIII cycle, tutor: M. Chiariello)



April 15, 2014 - Centro Didattico Le Scotte, 16.00-18.00

"Identification of new disease genes involved in nephropaties" - Bianciardi Laura (XXVIII cycle, tutor: F. Ariani)

"Characterization of lower limb cutaneous ulcers in systemic sclerosis: the analysis of 554 lesions" - Blagojevic Jelena (XXVIII cycle, tutor: M. Matucci Cerinic)

"New molecular markers for the screening of myelodysplastic syndromes" - Ciabatti Elena (XXVIII cycle, tutor: S. Galimberti)

"Characterization of the phenotypic responses in metastatic melanoma patients in the course of immunotherapy with anti-CTLA-4 blockade" - Cutaia Ornella (XXVIII cycle, tutor: M. Maio)

"Synaptic Changes associated with CDKL5 mutations" - Patriarchi Tommaso (XXVII cycle, tutor: A. Renieri)



April 4, 2014 - Centro Didattico Le Scotte, 16.00-18.00

"Mutational study of p53 in patients with Relapsed/Refractory Multiple Myeloma" - Lucani Benedetta (XXVII cycle, tutor: M. Bocchia)

"The role of immuno-monitoring as predictive marker in metastatic melanoma patients treated with different immunotherapy regimens" - Danielli Riccardo (XXVII cycle, tutor: M. Maio)

"Prognostic potential of epigenetic markers in cutaneous melanoma" - Parisi Giulia (XXVII cycle, tutor: M. Maio)

"Alteration of aortic constituents in thoracic aortic aneurysm and role of MMPs, TIMPs and GGT in the pathogenesis of the disease" - Gazaneo Sara (XXVII cycle, tutor: P. Tanganelli)



March 25, 2014 - Centro Didattico Le Scotte, 16.00-18.00

"The role of haematological markers in patients undergoing thymectomy: a study from United Kingdom" - Granato Felice (XXVI cycle, tutor: S. Civitelli)

"Role of cross-talk between platelets and lympho-monocytes in tissue repair and wound healing" - Nami Niccolò (XXVII cycle, tutor: M. Fimiani)

"APOBEC1: a possible role in melanoma growth and stemness" - Pietrobono Silvia (XXVII cycle, tutor: B. Stecca, S. Conticello)

"Experimental evaluation of computationally designed peptides with high affinity for a target protein" - Russo Anna (XXVII cycle, tutor: A. Giordano)

"Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment" - Ruvio Martina (XXVII cycle, tutor: R. Nuti)



February 20, 2014 - Centro Didattico Le Scotte, 16.00-18.00

"Possible protective role of some Mediterranean diet foods in relation to cancer" - Barone Daniela (XXVII cycle, tutor: A. Giordano)

"New pyrazolo[3,4-d]pyrimidine SRC inhibitors as potential candidates for malignant astrocytomas therapy" - Ceccherini Elisa (A. Giordano)



February 4, 2014 - Centro Didattico Le Scotte, 16.00-18.00

"Role of KRAS mutation as predictor of pathologic response after neoadjuvant chemoradiation therapy for rectal cancer" - Martellucci Jacopo (XXVI cycle, tutor: S. Civitelli)

"Hereditary breast and ovarian cancer" - Mencarelli Maria Antonietta (XXVI cycle, tutor: A. Renieri)

"Estrogens promote tumor formation by inducing hypoxia" - Rizzo Valeria (XXVI cycle, tutor: A. Giordano)

"Proteomic approach to characterize Idiopathic Pulmonary Fibrosis and its different clinical phenotypes" - Carleo Alfonso (XXVII cycle, tutor: P. Rottoli)



January 21, 2014- Centro Didattico Le Scotte, 16.00-18.00

"New strategies for the treatment of rhabdomyosarcoma" - Casini Nadia (XXVI cycle, tutor: A. Giordano)

"Unbiased Next Generation Sequencing analysis confirms the existence of autosomal dominant Alport syndrome in a relevant fraction of cases" - Fallerini Chiara (XXVI cycle, tutor: F. Mari)




LAB MEETING SCHEDULE ACADEMIC YEAR 2012-2013

13 June 2013 - Room 7, Centro Didattico, 16.00-18.00

"Mutational study of P53 in patients with multiple myeloma relapsed / refractory" - Lucani Benedetta (XXVII ciclo, tutor: M. Bocchia)

"Adenosine modulation in the process of cardiopulmonary fibrosis. Bio-molecular characterization of receptor subtypes at tissue and peripheral level" - Della Latta Veronica (XXVIII ciclo, tutor: A. Morales)

"Expression and function of the P2X7 receptor in dermal fibroblasts from patients with Systemic Sclerosis" - Gentile Daniela (XXVIII ciclo, tutor: F. Laghi Pasini)

"Role of neutrophils activation in the pathogenesis of systemic juvenile idiopathic arthritis" - Magnotti Flora (XXVIII ciclo, tutor: M. Galeazzi)

"Setup of a system for the evaluation of cellular autophagy" - Merelli Eva (XXVIII ciclo, tutor: M. Chiariello)



30 May 2013 - Room 9, Centro Didattico, 16.00-18.00

"Identification of new disease genes involved in nephropaties" - Bianciardi Laura (XXVIII ciclo, tutor: F. Ariani)

“Characterization of Lower Limb Cutaneous Lesions in Systemic Sclerosis: the Analysis of 424 Lesions” - Blagojevic Jelena (XXVIII ciclo, tutor: M. Matucci Cerinic)

“Urinary proteomic biomarkers in lupus nephritis: preliminary data” - Carli Linda (XXVIII ciclo, tutor: M. Mosca)

"Molecular markers for diagnosis and prognosis of patients affected by myelodisplastic syndromes" - Ciabatti Elena (XXVIII ciclo, tutor: S. Galimberti)

“Characterization Of The Humoral Responses In Patients With Advanced Metastatic Melanoma In The Course Of Immunotherapy With Anti-Ctla-4 Blockade” - Cutaia Ornella (XXVIII ciclo, tutor: M. Maio)



14 May 2013 - May 14, 2013- Room 11, Centro Didattico, 16.00-18.00

"Alteration of aortic constituents in thoracic aortic aneurysm and role of MMPs,TIMPs and GGT in the pathogenesis of the disease" - Gazaneo Sara (XXVII ciclo, tutor: P. Tanganelli)

"Possible protective role of some Mediterranean diet foods in relation to gastric cancer: inside molecular pathways" - Barone Daniela (XXVII ciclo, tutor: A. Giordano)

"Role of APOBEC1 in melanoma stemness" - Pietrobono Silvia (XXVII ciclo, tutor: B. Stecca)

“Computational studies and experimental evaluation of high affinity peptide-protein interactions” - Russo Anna (XXVII ciclo, tutor: A. Giordano)

“Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment” - Ruvio Martina (XXVII ciclo, tutor: R. Nuti)

"Synaptic changes associated with CDKL5 mutation" - Patriarchi Tommaso (XXVII ciclo, tutor: A. Renieri)



23 April 2013 - Room 10, Centro Didattico, 17.00-19.00

- New pyrazolo[3,4-d]pyrimidine SRC inhibitors as potential candidates for malignant astrocytomas therapy (Ceccherini Elisa, XXVII ciclo, tutor: A. Giordano)

- Genetics and tolerance of virtual reality distraction intervention in cancer patients (Milanese Carla, XXVII ciclo, tutor: A. Giordano)

- Role of cross-talk between platelets and leucocytes in skin repair and in immune-mediate diseases (Nami Niccolò, XXVII ciclo, tutor: M. Fimiani)

- Evaluation of the potential anticancer activity of a RB2-derived small molecule on glioblastoma cell line (Napoliello Luca, XXVII ciclo, tutor: A. Giordano)

- Prognostic potential of Epigenetic markers in cutaneous melanoma (Parisi Giulia, XXVII ciclo, tutor: M. Maio)



27 March 2013 - Room 9, Centro Didattico, 16.00-18.00

"22q11.2 micro-deletion and MURCS association syndrome" - Amabile Sonia (XXVII ciclo, tutor: F. Mari)

"Proteomic Analysis of BronchoAlveolar Fluid Lavage in patients with Idiopathic Pulmonary Fibrosis" - Carleo Alfonso (XXVII ciclo, tutor: P. Rottoli)

"The role of immuno-monitoring as predictive marker in metastatic melanoma patients treated with DACARBAZINE AND THYMOSIN ALFA 1 within an expanded access program (EAP)" - Danielli Riccardo (XXVII ciclo, tutor: M. Maio)



LAB MEETING SCHEDULE ACADEMIC YEAR 2011-2012

1 August 2012 h 16.30 - 19.30 room 15 San Miniato

- New pyrazolo[3,4-d] pyrimidine SRC inhibitors as potential candidates for malignant astrocytoma therapy (Elisa Ceccherini, Oncological Genetics, XXVII cycle, tutor: A. Giordano)

- Genetics of Retinoblastoma predisposition (Moen Riaz, Medical Genetics, XXVII cycle, tutor: A. Renieri)

- New strategies for the study and treatment of rhabdomyosarcoma (Nadia Casini, Oncological Genetics, XXVI cycle, tutor: A. Giordano)

- 22q11.2 micro-deletion and MURCS association syndrome: mutation in non-deleted allele as a possible cause of MURCS association phenotype (Sonia Amabile, Medical Genetics, XXVII cycle, tutor: A. Renieri)

- Targeting the checkpoint kinase WEE1 for cancer therapy (Eleonora Marcelli, Experimental Medicine and Atherosclerosis, XXVI cycle, tutor: P. Tanganelli)

- A Novel Role for Relaxin (RLX) and its Receptor (LGR7) in Limited Systemic Sclerosis (lSSc) (Claudio Corallo, Osteo-Metabolic Diseases, XXVI cycle, tutor: N. Giordano)

- The role of surgical lung biopsy in the management of undefined parenchymal lung disease (Felice Granato, Hepathobiliopancreatic Diseases and Multitumoral Syndromes, XXVI cycle, tutor: S. Civitelli)

- Synaptic changes associated with CDKL5 mutations (Tommaso Patriarchi, Medical Genetics, XXVII cycle, tutor: A. Renieri) Videoconference from the University of California, Davis

- CSF microRNAs in HIV-associated neurological disorders (Marco Pacifici, Oncological Genetics, XXIV cycle, tutor: A. Giordano) Videoconference from LSU Health Sciences Center, New Orleans



18 July 2012 h 16.30 - 19.30 room 15

- Identification of human ANP amyloid in young patients affected by Congestive Heart Failure (Sara Gazaneo, Experimental Medicine and Atherosclerosis, XXVII cycle, tutor: P. Tanganelli)

- APOBEC-1: a possible role in cancer stemness? (Silvia Pietrobono, Oncological Genetics, XXVII cycle, tutor: B. Stecca)

- Evaluation of the potential anticancer activity of a RB2-derived small molecule on malignant glioblastoma cell line (Luca Napoliello, Oncological Genetics, XXVII cycle, tutor: A. Giordano)

- Synthesis and biofunctionalization of gold nanoparticles: excellent drug-carrier and diagnostic tools (Anna Russo, Oncological Genetics, XXVII cycle, tutor: A. Giordano)

- The Role of Platelet-Rich Plasma in Tissue Regeneration (Stefania Mei, Clinical and Experimental Allegology and Immunology, XXVII cycle, tutor: M. Fimiani)

- The role of immuno-monitoring as predictive marker in metastatic melanoma patients treated with different immunotherapy regimens (Riccardo Danielli, Clinical and Experimental Allegology and Immunology, XXVII cycle, tutor: M. Maio)

- Laparoscopic total mesorectal excision for rectal cancer: long-term
results (Iacopo Martellucci, Hepatobiliopancreatic Diseases and Multitumoral Syndromes, XXVI cycle, tutor: S. Civitelli)



4th July 2012 h 16.30- 19.30 room 3

- Genetics and tolerance of virtual reality distraction intervention in cancer patients (Carla Milanese, Oncological Genetics, XXVII cycle, tutor: A. Giordano)

- Study of cross-talk between mononuclear cells and platelets in the pathogenesis of moderate-severe psoriasis and their role in the metabolic disease linked to the skin disorder (Nami Niccolò, Clinical and Experimental Allergology and Immunology, XXVII cycle, tutor: M. Fimiani)

- Whole genome methylation profiles and survival of melanoma patients (Giulia Parisi, Clinical and Experimental Allergology and Immunology, XXVII cycle, tutor: M. Maio)

- Mutational study of p53 in patients with multiple myeloma Relapsed/Refractory (Benedetta Lucani, Clinical and Experimental Allergology and Immunology, XXVII cycle, tutor: M. Bocchia)

- Proteomic approach to characterizing interstitial pulmonary diseases (Alfonso Carleo, Clinical and Experimental Allergology and Immunology, tutor: P. Rottoli)

- BMD follow up evalation in patients with Cerebrotendinous Xanthomatosis (Martina Ruvio, Osteo-Metabolic diseases, XXVII cycle, tutor: R. Nuti)

- Possible protective role of some Mediterranean diet foods in relation to gastric cancer (Daniela Barone, Oncological Genetics, XXVII cycle, tutor: A. Giordano)



6th June 2012 h 16.30 - 19.30 room 7

- P2X7 Receptor Protein in Multiple Sclerosis (Cinzia Montilli, Clinical Pharmacology, XXV cycle, tutor: F. Laghi Pasini)

- Purinergic receptors and cardiac remodeling (Stefania Zimbone, Clinical Pharmacology, XXVI cycle, tutor: F. Laghi Pasini)

- Life at the extreme limit: phenotypic characteristics of 100 centenarians admitted to geriatric institute 'Pio Albergo Trivulzio (Valentina Guercio, Hepatobiliopancreatic diseases and multitumoral syndromes, XXV cycle, tutor: F. Cetta)

- Analysis and immunoistochemistry of decorin in localized scleroderma before and after UVA-1 treatment (Pianigiani Anna Paola, Clinical and Experimental Allergology and Immunology, tutor: M. Fimiani)

- Recessive phenotypes in 22q11.2 region (Mucciolo Mafalda, Medical Genetics, XXIV cycle, tutor: F. Mari)

- Integrating role of T-antigen, Rb2/p130, CTCF and Boris in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by ER-chronic stress in mouse medulloblastoma (Valeria Rizzo, Oncological Genetics, XXVI cycle, tutor: A. Giordano) - Videoconference from Philadelphia



9th May 2012 h 16.30 - 19.30 room 7

- A new gene contiguous syndrome at 22q13, not involving SHANK3 gene (Maria Antonietta Mencarelli, Medical Genetics, XXVI cycle, tutor: A. Renieri) 10 min

- Small molecules mimicking the spa310 peptide from the spacer region of pRB2/p130 as potential
anticancer agents (Conti Daniele, Oncological Genetics, XXIV cycle, tutor: A. Giordano)

- Possible role of densitometry of the hand in the prognostic assessment and therapeutic monitoring of rheumatoid arthritis. Correlation with instrumental, clinical and biochemical indices (Bertoldi Ilaria, Experimental Rheumatology, XXV cycle, tutor: M. Galeazzi)

- Chemerin role in chronic inflammatory arthritis (Valcamonica Elisabetta, Experimental Rheumatology, XXV cycle, tutor: M. Galeazzi)

- LOX-1 genetic variants distribution, similarities and differences between the Caucasic population and sub saharian african population in primary and secondary prevention in relation to existing classic risk factors for atherothrombosis (Kimani Jane Lucie, Experimental Medicine and Atherosclerosis, XXV cycle, tutor: L. Puccetti)

- Outcome of surgical treatment of colorectal cancer in the elderly (Fontani Andrea, Colorectal and Gastroesophageal Disease, XXV cycle, tutor: S. Civitelli)



11th April 2012 h 16.30 - 19.30 room 7

ERK8 involvement in autophagy (David Colecchia, Medical Genetics, XXIV cycle, tutor: M. Chiariello)

Genetic screening and clinical therapeutical implications in Paget's disease of bone (Merlotti Daniela, Osteo-Metabolic diseases, XXV cycle, tutor: R. Nuti)

Antitumor activity of new pyrazolo pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines (Cozzi Martina, Oncological Genetics, XXIV cycle, tutor: A. Giordano)

Rett Networked Database: an integrated clinical and genetic network of Rett syndrome databases (Grillo Elisa, Medical Genetics, XXV cycle, tutor: F. Ariani)

Bioinformatics approach for detecting and quantifying the amount of metastasis in cancer tissue (Olaynka Olabinjo, Oncological Genetics, XXV cycle, tutor: A. Giordano) - Videoconference from Philadelphia




7th March 2012 h 16.30 - 19.30 room 3

- New strategies for the cure of malignant mesothelioma by using p53 activating molecules (Iris Maria Forte, Oncological Genetics, XXIV cycle, tutor: A. Giordano)

- Identification of a novel p190-derived breakpoint peptide suitable for peptide vaccine therapeutic approach in Ph+ acute lymphoblastic leukemia patients (Defina Marzia, Clinical and Experimental Allergology and Immunology, XXV cycle, tutor: M. Bocchia)

- The involvement of inflammation and oxidative stress biomarkers into two different studies: evaluation in experimental models and in humans (Zangari Rosalia, Hepatobiliopancreatic diseases and Multitumoral syndromes, XXIV cycle, tutor: F. Cetta)

- The key role of interleukin 17 in psoriasis and other autoimmune diseases (Cervadoro Elisa, Clinical and Experimental Allergology and Immunology, XXV cycle, tutor: M. Fimiani)



1st February 2012 h 16.30 - 19.30 room 4

- Analysis of aberrant constitutional DNA methylation in patients with colorectal cancer and multiple primary tumors (20’ Crucianelli Francesca, Colorectal and gastroesophageal diseases, XXIV cycle, tutor: S. Civitelli, M. Genuardi)

- New technologies to study Rett syndrome (20’ Gabriella Livide, Medical Genetics, XXV cycle, tutor: F. Ariani, A. Renieri)

- Alteration of aortic constituents in thoracic aortic aneurysm and role of MMPs, TIMPs and GGT in the pathogenesis of the disease (20’ Cappelli Alessia, Experimental Medicine and Atherosclerosis, XXVI cycle, tutor: P. Tanganelli)



14th December 2011 h 16.30 - 19.30

- Analysis of phenotype risks/environmental factors and serum levels of 1,25-dihydroxy vitamin D3 in patients with “fast growing melanoma” (20’ Mandato Filomena, Clinical and experimental Allergology and Immunology, XXVI cycle, tutor: M. Fimiani)

- Prognostic significante of IGHV1-69 gene in Chronic Lynphocytic Leukemia (20’Sicuranza Anna, Clinical Pharmacology, XXVI cycle, tutor: M. Bocchia)

- Investigating new microdeletion syndromes (20’ Disciglio Vittoria, Medical Genetics, XXIV cycle, tutor: F. Mari, A. Renieri)

- Alport syndrome and Next Generation Sequencing (20’ Chiara Fallerini, Medical Genetics, XXVI cycle, tutor: A. Renieri)