The main aim of medical research is to define the molecular basis of diseases and to translate scientific knowledge in concrete applications for diagnosis, prevention, and treatment of diseases.
The PhD student will acquire theoretical and practical knowledge on the latest molecular techniques such as “array-CGH”, “next-generation sequencing” and “genetic reprogramming” that allows obtaining iPS (induced Pluripotent Stem cells) from adult human fibroblasts and to differentiate them into neurons or other cellular types (educational training in Medical Genetics). Specific educational training focused on pharmacogenomics is aimed at the identification of personalized therapy for each individual (educational training in Pharmacogenetics and clinical pharmacology). Particular attention will be given to the molecular basis and therapeutic strategies of cancer. The PhD student will be able to: i) carry out clinical-epidemiological-observational studies of thoracic and intestinal cancers (educational training in Surgical oncology), of melanomas and onco-haematopoiesis (educational training in Hematological oncology and dermatological oncology); ii) choose the appropriate molecular methods to identify new targets for the design of targeted therapies and new diagnostic, prognostic and predictive markers for therapy response (educational training in Oncological Genetics). One educational training focused on Clinical Immunology, will train researchers capable of developing research projects concerning rare diseases including immune idiopathic pulmonary fibrosis, emphysema-alpha-1-antitrypsin deficit and rare autoimmune and autoinflammatory rheumatic diseases. This educational training will also train researches with pre-clinical and clinical expertise to develop new targeted therapeutic agents and new strategies for cancer immunotherapy.
Students will be attending only one of the above
mentioned courses, at the end of which they will obtain the PhD title in
Oncology and Genetics.
Starting from the first year, students
will develop their own research, under the direction of a supervisor
chosen among the Faculty Board of the Doctoral School.
Laboratory
spaces available for students are located at 1st floor 3rd block
(Laboratory of Medical Genetics with 20 workstations) and at ground
floor educational block (Laboratory of Biomedical Technologies and
Experimental Oncology with 18 workstations) of Policlinico S Maria alle
Scotte, Viale Bracci 2, Siena and inside Toscana Life Sciences (TLS)
Foundation, via Torre Fiorentina 1 (ITT Core Research Laboratory, Signal
Transduction Unit). Detailed laboratory description
PhD
students will spend from 70% to 90% of their time in a laboratory using
the current techniques of molecular genetics and cell biology. Students,
with MD degree, can use about 20% of their time in the clinical
activity being in contact with patients for whom research project will
be designed. The remaining 10% of the time will be devoted to lessons and seminars held by Faculty Board or foreign professors (see “seminars” link for those already held). Students are encouraged to undertake
periods of research in foreign academic institutions, as long as it
helps them make progress in their research; for this purpose, they will
receive financial support from the University of Siena (see below).
Every
year, students present the state of their research in a public seminar.
Based on this seminar and on reaching at least 60 credits, it is decided on the admission to the following year. Credits can be obtained
as follows:
- Annual Presentation at PhD day (Presentation max 5; Content max 5; Questions +/- 1; Final test max 4)
- Publication on international journal (20 credits if first author, 15 credits if co-author)
- Participation at congresses with abstract presentation (8 credits for international congress, 5 credits for national congress)
- Participation at congresses with oral presentation (15 credits for international congress, 10 credits for national congress)
- Participation to progress reports and GenOMeC seminars (10 credits)
- National stages (1 credit/week)
- International stages (2 credits/week)
- Patent (5 credits)
- Collaboration to teaching activity (max 4 credits for each course for which the PhD student is appointed "collaboratore alla didattica") .
The PhD is awarded after discussion of an original scientific work. This must be written in English.
Further information:
All
internal decisions about the doctorate are taken by the Faculty Board (Collegio dei Docenti), whose coordinator is Prof. Francesca Ariani.
Queries on matters under the competence of the "Collegio Docenti" and requests for further information can be addressed to doctorate.genomec@dbm.unisi.it.