University of Siena
Department of Medical Biotechnologies
Department of Medical Biotechnologies
PhD Programme in
Genetics, Oncology and Clinical Medicine
Lab Meeting Programme
Progress report schedule, academic year 2023-2024
March 22nd, 2024 at 5pm
- Caterina Baccioni (tutor : Researcher Silvo Conticello)
Title: APOBEC and ADAR involvement in SARS-CoV-2 infection and cancer implications
- Elena Iacono (tutor : Researcher Michele Lai)
Title: Targeting N-Acylethanolamine Acid Amidase as a host strategy to coumetabolism snd viral maturationnteract flavivirus Infection:implications for lipid
- Gabriele Martelloni (tutor : Prof. Alessandra Renieri)
Title: Machine learning and new diagnostic approaches
- Erika Plicanti (tutor : Prof. Giulia Freer)
Title: Screening of antiviral compounds against Zika virus and creation of drug-resistant viral mutants
April 05th, 2024 at 5pm
- Elena Tofacchi (tutor : Prof. Valeria Santini)
Title: Inflammation versus inflammation in MDS: is aging a pre-MDS state?
- De Pourcq Sven (tutor : Prof. Valeria Santini)
Title: DNA methylation as determinant in novel hypomethylating agent (HMA) combination therapies for treatment of high-risk MDS patients
- Giulia Brunelli (tutor : Researcher Romina D'Aurizio)
Title: Multi-omics data integration for the study of complex diseases
April 12th, 2024 at 5pm
- Di Re Flavia (tutor : Prof. F. Mari)
Title: Personalized therapy in patients with Chronic Lymphocytic Leukemia (CLL)
- Colasurdo Rosella (tutor : Prof. A. Arcangeli )
Title: Development and characterization of a novel antibody platform to be exploited for cancer diagnosis and therapy
- De Carli Alessandro (tutor : Prof. G. Freer)
Title: Nanoparticles for In vivo gene editing: improving delivery, activity and safetiness of CRISPR/Cas proteins
- Giorli Alessia (tutor : Prof. M. Mandalà)
Title: G5X Alport Syndrome mouse model hearing characterization for a future preclinical application of CRISPR/Cas9
April 19th, 2024 at 5pm
- Tommaso Innocenti (tutor : Prof. A. Galli)
Title: Exploring the role of miRNAs in inflammatory bowel disease using patient-derived intestinal organoids: predictive biomarkers and new therapeutic targets
- Martina Rozza (tutor : Prof. A. Renieri )
Title: Tissue engineering and bone regeneration: The precious role of mesenchymal stem cell
- Michele Martinelli (tutor : Prof. A. Arcangeli)
Title: Identification of novel therapeutic strategies through newly developed in vivo tumor models.
- Ismael Cem Nass Kebapcioglu (tutor : Prof. S. Conticello)
Title: Targeting Cancer Through RNA Editing Induced Synthetic Lethality
May 10th, 2024 at 5pm
- Erica Nicola Lynch (tutor : Prof. A. Galli)
Title: NEurotrophin MImetic compound for the modulation of ischemia-reperfusion injury in liver transplantation with Extended criteria Donors - the NEMILED study.
- Dina Zucchi (tutor : Prof. M. Mosca )
Title: Targeting steroid withdrawal in systemic lupus erythematosus
- Maria Conceta Pastore (tutor : Prof. M. Cameli)
Title: Multimodality imaging for the detection of cardiotoxicity in cancer patients treated with immune checkpoint inhibitors
- Cecilia Anceschi (tutor : Prof. F. Margheri)
Title: Integrating molecular features into biological effects of radiotherapy and nano- based hyperthermia in breast cancer
- Martina Lanza (tutor : Prof. L. Poliseno)
Title: Establishment of an in vitro system for the characterization of BRAFV600E splicing variants: ref and X1
May 17th, 2024 at 5pm
- Alessio Menconi (tutor : Prof. E. Rovida)
Title: Role of ERK5 in liver pathophysiology
- Elisa Troiano (tutor : Prof. S. Giannotti)
Title: 3D CT scan-based pre-operative planning and intra-operative navigation for glenoid component fixation in reverse shoulder arthroplasty
- Simona Innamorato (tutor : Prof. A. Renieri)
Title:Cell-Free DNA Liquid Biopsy as Prognostic and Predictive Biomarker in Solid Cancers
- Marta Roncetti (tutor : Prof. L. Poliseno)
Title: Improvement of the efficacy of the attenuated bacterium Listeria monocytogenes as anticancer vaccine through cell wall functionalization using bio-orthogonal click chemistry
- Viola Bianca Serio (tutor : Prof. E. Frullanti)
Title: CfDNA NGS-Liquid Biopsy: a new strategy to face different advanced solid cancers
May 24th, 2024 at 5pm
- Tommaso Bacci (tutor: Prof. G. Tosi)
Title: Improving the imaging and molecular biomarker armamentarium in age-related macular degeneration: searching for new indicators of disease progression and molecular therapeutic targets
- Nicoletta Mancianti (tutor : Prof. G. Garosi)
Title: RNA Expression and Histological Changes in Renal Graft Pre- and Post-machine perfusion
- Gaida Agostini (tutor : Prof. S. Conticello)
Title: Epitranscriptomics changes in physiology and pathology
- Franciska Piccolo (tutor : Prof. M. Morelli)
Title:Genetic and molecular basis and ethnic differences in oncological diseases
- Claudio Cirrincione (tutor : Prof. M. Morelli)
Title:Quantitative analysis of salivary IGF1 levels in growing patients as a non-invasive method for the assessment of a reliable biomarker before orthodontic therapy
May 31st, 2024 at 5pm
- Michele Santillo (tutor : Prof. E. Lastraioli)
Title: Liquid biopsy for the evaluation of molecular alterations in human cancer
- Dario Rosini (tutor : Prof. M. De Angioletti)
Title: The Role of ERG, an ETS Transcription Factor, in the modulation of Immuno Regulatory Proteins PD-L1 and CD4
- Chiara De Vellis (tutor : Prof. B. Stecca)
Title: The role of ST3GAL1 in immune escape: a hallmark of melanoma progression
- Maurizio Salvatore Podda (tutor : Prof. L. Poliseno)
Title: In silico investigation of BRAFV600E regulatory networks in melanoma
- Carmen Piazza Rita (tutor : Prof. G. Freer)
Title: Evaluation of the therapeutic efficacy of the gene editing system based on the use of a photo-inducible CRISPR/Cas9 in a mouse model of melanoma
June 7th, 2024 at 5pm
- Danilo Tatoni (tutor : Prof. R. D'Aurizio)
Title: Identifying cancer neoepitopes from transcriptomic data
- Franco D'Alessandro (tutor : Prof. A. Arcangelli)
Title: New approaches to understand the role of potassium channels and their interaction with tumor microenvironment (TME) for innovative therapy
- Chiara Cardelli (tutor : Prof. M. Mosca)
Title: Cutaneous involvement in Systemic Lupus Erythematosus: novel diagnostic approaches, serum biomarkers, and response to treatment in different disease phenotypes
- Giuseppe Lo Scocco (tutor : Prof. A. Vannuchi)
Title: Clinical, histopathological, cytogenetic and molecular characterization of myeloid sarcoma
June 14th, 2024 at 5pm
- Matteo Capecchi (tutor : Prof. S. Gonnelli)
Title: Sex Hormones in Long QT Syndrome and Torsades de Po
- Ilaria Gisone (tutor : Prof. M. Morales)
Title: Biological modulation study induced by xenobiotics on cardiomyocyte cell cultures
Progress report schedule, academic year 2022-2023
March 23rd, 2023 at 5pm
- Margherita Baldassarri (tutor : Prof. Francesca Mari)
Title: Clinical variability of COVID-19 due to host genetics: an ongoing Tuscan project
-Chiara Capitani (tutor : Prof. Annarosa Arcangeli)
Title: Ion channels and transporters in breast cancer: promising targets of novel recombinant antibodies
-Alessandra Cartocci (tutor : Prof. Pietro Rubegni/ Gabriele Cevenini)
Title: A convolutional neural network approach for a multiclass classification task: the facial skin lesion project
-Luna Cavigli (tutor : Prof. Flavio D'Ascenzi)
Title: EPICH- Exercise Prescription In Cardiomyopathies and Heart transplant
March 30, 2023 at 5pm
-Ginevra Chioccioli Altadonna (tutor : Prof. Annarosa Arcangeli)
Title:Study And Functional Characterization Of Potassium Channels Network In The Pancreatic Ductal Adenocarcinoma (PDAC) For InnovativeTherapeutic Strategies
-Carla Gaggiano (tutor : Prof. Luca Cantarini)
Title: A patient-driven registry on Behçet’s syndrome: the AIDA for Patients pilot project
-Alice Guida (tutor : Prof. Andrea Galli/Mello Tommaso)
Title: RuvBL1 haploinsufficiency promotes hepatic lipid catabolism hampering NASH-HCC progression in mice
April 13, 2023 at 5pm
-Giulia Lottini (tutor : Prof. Giulia Freer)
Title: Zika virus induces FOXG1 nuclear displacement and down-regulation
-Ignazio Martellucci (tutor : Prof. Marco Mandalà)
Title: Head and Neck Cancer and liquid biopsy: analysis on metachronous multiple primary tumors
-Giulio Menegazzi (tutor : Prof. Persio Dello Sharba)
Title: Metabolic modulation of stem cell potential maintenance in Chronic Myeloid Leukaemia cell cultures
-Antonella Prantera (tutor : Prof. Laura Poliseno)
Title: The LNA inhibitor of miR-204 induces massive apoptotic cell death in melanoma cells through p53 pathway
April 20th, 2023 at 5pm
-Marta Puzzono (tutor : Prof. Andrea Galli/ Giulia Martina Cavestro)
Title: Association of endogenous and exogenous factors with early-onset colorectal cancer (eoCRC): germline mutations, LINE-1, plasma circulating miRNAs, dietary pattern, obesity, lifestyle habits
-Diletta Rosati (tutor : Prof. Antonio Giordano)
Title: Malignant pleural mesothelioma: clinicopathologic and survival analysis
-Laura Solmonese (tutor : Prof. Michele Maio)
Title: Development of anti-tumor combination approaches of a cell-based cancer vaccine
-Jurgen Sota (tutor : Prof. Luca Cantarini)
Title: Characterization of immune-mediated rheumatic diseases induced by immune checkpoint inhibitors in oncologic patients
-Kristina Zguro (tutor : Prof. Simone Furini)
Title: Alport and Rett syndrome: explanation of incomplete penetrance and variable expressivity
April 27th, 2023 at 5pm
-Lucia Vietri (tutor : Prof. Elena Bargagli)
Title: Serum Amyloid A: a new biomarker in interstitial lung diseases
-Tommaso Bacci (tutor : Prof. Gian Marco Tosi)
Title: Improving the imaging and molecular biomarker armamentarium in age-related macular degeneration: searching for new indicators of disease progression and molecular therapeutic targets
-Caterina Baccioni (tutor : Researcher Silvo Conticello)
Title: APOBEC and ADAR involvement in SARS-CoV-2 infection
-Giulia Brunelli (tutor : Researcher Romina D'Aurizio)
Title: Accurate and fast computational workflow for copy number variant detection up to single exon from clinical exome sequencing
-Chiara De Velis (tutor : Researcher Barbara Stecca)
Title: The role of ST3GAL1 in immune escape: a hallmark of melanoma progression
May 11th, 2023 at 5pm
- Marco Di Battista (tutor : Prof. Marta Mosca)
Title: Clinical and laboratory assessment of dysautonomia in patients with systemic sclerosis
-Flavia Di Re (tutor : Prof. Francesca Mari)
Title: Personalized therapy in patient with Chronic Lymphocytic Leukemia
-Ilaria Gisone (tutor :Researcher Maria Morales)
Title: Biological modulation study induced by xenogens on cardiomyocyte cell cultures
-Carmen Rita Piazza (tutor : Prof. Giulia Freer)
Title: Evaluation of the therapeutic efficacy of a gene editing system based on the use of a photo-inducible CRISPR/Cas9 in different melanoma models
-Maurizio Salvatore Podda (tutor :Researcher Laura Poliseno)
Title:Comprehensive Investigation of BRAF Isoform-Specific Expression: Analyzing the Expression Profiles of BRAF Reference and X1 Transcripts in Melanoma and Beyond using RNA-seq Analysis
May 18th, 2023 at 5pm
- Marta Roncetti (tutor : Researcher Laura Poliseno)
Title: Improvement of the efficacy of the attenuated bacterium Listeria monocytogenes as anticancer vaccine through cell wall functionalization using bio-orthogonal click chemistry
-Dario Rosini (tutor :Researcher Rosario Notaro)
Title:The Role of ETS Transcription Factors in the Modulation of Immuno-Regolatory Proteins PD-L1 and CD47
-Sven De Pourq (tutor :Prof. Valeria Santini)
Title:DNA methylation as a determinant for MDS: Why are we still speaking about this?
-Viola Bianca Serio (tutor :Prof. Elisa Frullanti)
Title:Liquid Biopsy as a new strategy to face advanced cancers from different solid primary tumors
-Alessandro De Carli (tutor :Prof. Giulia Freer/Michele Lai)
Title:Nanoparticles for Enhanced Gene Editing: Improving Delivery, Activity, and Safety of CRISPR/Cas Proteins
May 25th, 2023 at 5pm
- Matteo Capecchi (tutor : Prof. Stefano Gonnelli)
Title: Sex hormones in Long QT syndrome and torsades de pointes
- Alessia Giorli (tutor : Prof. Marco Mandalà)
Title: Hearing Testing on Alport Mouse for a future preclinic application of CRISPR/Cas9
- Giuseppe Gaetano Loscocco (tutor : Prof. Alessandro Maria Vannucchi)
Title: Clinical, histopathological, cytogenetic and molecular characterization of myeloid sarcoma
- Dina Zucchi (tutor : Prof. Marta Mosca)
Title: Targeting steroid withdrawal in systemic lupus erythematosus
- Michele Martinelli (tutor : Prof.Annarosa Arcangeli)
Title: Identification of novel therapeutic strategies through newly developed in vivo tumor models
June 1st, 2023 at 5pm
- Franco D'Alessandro (tutor : Prof. Annarosa Arcangeli)
Title: New Approaches to understand the role of potassium channels and their interaction with tumour microenvironment (TME) for innovative targeted therapy
- Elena Tofacchi (tutor : Prof. Valeria Santini)
Title:Inflammaging versus inflammation in MDS: is aging a pre-MDS state?
- Gabriele Martelloni (tutor : Prof. Alessandra Renieri)
Title:Correlation between host genetics and COVID-19 severity
- Ismael Cem Nass Kebapcioglu (tutor :Researcher Silvo Conticello)
Title:Targeting cancer through RNA-editing induced synthetic lethality
June 8th, 2023 at 5pm
- Giada Agostino (tutor :Researcher Silvo Conticello)
Title: Epitranscriptomics changes in physiology and pathology
- Antonella Al Refaie(tutor : Prof. Stefano Gonnelli)
Title: The potential usefulness of Radiofrequency Echographic Multi Spectrometry technology (REMS) and new biochemical markers in the assessment of musculoskeletal interactions
- Rossella Colasurdo (tutor : Prof. Santini Valeria)
Title: Development and characterization of a novel antibody platform to be exploited for cancer diagnosis and therapy
- Francesco Bianchi (tutor : Prof. Elena Bargagli)
Title: Role of biomarkers in COVID-19 pandemic: implications for acute-phase treatment and chronic management
June 15th, 2023 at 5pm
- Chiara Cardelli (tutor : Marta Mosca)
Title: Cutaneous involvement in Systemic Lupus Erythematosus: novel diagnostic approaches, serum biomarkers and response to treatment in different disease phenotypes
- Claudio Cirrincione (tutor : Prof. Annamaria Morelli)
Title: Quantitative analysis of salivary IGF1 levels in growing patients as non-invasive method for the assessment of a reliable biomarker before orthodontic therapy
- Cecilia Anceschi (tutor : Researcher Francesca Margheri)
Title: Integrating molecular features into biological effects of radiotherapy and nano-based hyperthermia in breast cancer
- Elena Iacono (tutor :Prof. Giulia Freer)
Title:Targeting N-Acylethanolamine Acid Amidase as a host strategy to counteract flavivirus Infection: implications for lipid metabolism and viral maturation
June 22nd, 2023 at 5pm
- Tommaso Innocenti (tutor : Prof. Andrea Galli)
Title: Exploring the role of miRNAs in inflammatory bowel disease using patient-derived intestinal organoids: predictive biomarkers and new therapeutic targets
- Martina Lanza (tutor : Researcher Laura Poliseno)
Title: Establishment of an in vitro system for the characterization of BRAFV600E splicing variants: ref and X1
- Erica Nicola Lynch (tutor : Prof. Andrea Galli)
Title: NEurotrophin MImetic compound for the modulation of ischemia-reperfusion injury in liver transplantation with Extended criteria Donors - the NEMILED study
- Alessio Menconi (tutor : Prof. Elisabetta Rovida)
Title: Role of ERK5 in liver pathophysiology
- Maria Concetta Pastore (tutor : Prof. Matteo Cameli)
Title: Multimodality imaging for the detection of cardiotoxicity in cancer patients treated with immune checkpoint inhibitors
-Bianca Mecacci (tutor : Prof. Monica Bocchia/ Pietro Enea Lazzerini)
Title: Prognostic impact of B-vitamins and si gle nucleotide polymorphisms in patients with diffuse large B Cell lymphomas
July 13th, 2023 at 5pm
- Franciska Piccolo (tutor : Prof. Annamaria Morelli)
Title: Genetic and molecular basis and ethnic differences in oncological diseases
- Erika Plicanti (tutor : Prof. Giulia Freer)
Title: Screening of antiviral compounds against Zika virus and creation of drug-resistant viral mutants
- Angela Rina (tutor : Prof. Francesca Mari)
Title: Genomic profile of chronic lymphocytic leukemia
- Martina Rozza (tutor : Prof. Alessandra Renieri)
Title: Tissue engineering and bone regeneration: The precious role of mesenchymal stem cells
- Francesca Cersosimo (tutor : Prof. Antonio Giordano)
Title: Investigating the CSF-1R signaling in Malignant Mesothelioma
July 20th, 2023 at 5pm
- Michele Santillo (tutor : Researcher Elena Lastraioli)
Title: Liquid biopsy for the evaluation of molecular alterations in human cancer
- Danilo Tatoni (tutor : Researcher Romina D'Aurizio)
Title: Identifying cancer neoepitopes from transcriptomic data
-Elisa Troiano (tutor : Prof. Stefano Giannotti)
Title: CT scan-based pre-operative planning and intra-operative navigation for glenoid
-Giulia Vallini (tutor : Prof. Pietro Rubegni)
Title: Characterization of generic expression profile of psoriatic patients non-responder to anti-IL17A
-Giovanni Inzalaco (tutor : Researcher Mario Chiariello)
Title: The FHP01 DDX3X Helicase Inhibitor Exerts Potent Anti‐Tumor Activity in Vivo in Breast Cancer Pre‐Clinical Models
-Rachelle Bou Rjeily (tutor : Researcher Mario Chiariello)
Title: Pathophysiologic mechanisms by which adenomyosis predisposes to postpartum haemorrhage and other obstetric complications
-Simona Innamorato (tutor : Prof. Alessandra Renieri)
Title: Cell-Free DNA Liquid Biopsy as Prognostic and Predictive Biom
Progress report schedule, academic year 2020-2021
March 4th, 2021 at 5pm
- Torrini Serena (tutor Dr. Silvo Conticello)
Title: Evaluation of RNA editing mediated by APOBEC1 and APOBEC3A
- Romitelli Antonia (tutor Dr. Silvo Conticello)
Title: The role of Apobecs in Helitrons Transposition
- Capitani Katia (tutor Dr. Silvo Conticello)
Title: Gene editing of clinically-relevant mutations in IQSEC2-related intellectual disability
- Moccia Annalisa (tutor Dr. Maria De Angioletti)
Title: Role of ETS proteins in determining specific oncogenic phenotypes in prostate cancer
March 18th, 2021 at 5pm
- Franci Lorenzo (tutor Dr. Mario Chiariello)
Title: A new role for MAPK15 in metabolism
- Cameli Paolo (tutor prof. Elena Bargagli)
Title: For what it's worth: the role of urinary calcium in the management of interstitial lung diseases
- Bacchiarri Francesca (tutor prof. Monica Bocchia)
Title: A comprehensive evaluation of next-generation flow analysis, PD-L1, BCL-2, and FISH abnormalities of aberrant plasma cells in patients affected by smoldering multiple myeloma and multiple myeloma at the diagnosis
- Pacelli Paola (tutor prof. Monica Bocchia)
Title: Evaluation of Multiple Myeloma (MM) Minimal Residual Disease by using Next Generation Flow in patients undergoing Daratumumab therapy
- Vitale Antonio (tutor prof. Luca Cantarini)
Title: Real-Life Data on the Efficacy of Canakinumab in Patients with Adult-Onset Still's Disease
- Giani Teresa (tutor prof. Rolando Cimaz)
Title: Searching for new treatment targets in juvenile idiopathic arthritis: Immune checkpoints and tissue-resident memory T cells
March 25th, 2021 at 5pm
- d'Alessandro Miriana (tutor prof. Elena Bargagli)
Title: Serial Measurements of Krebs von den Lungen-6 in IPF Patients Treated with Antifibrotic Therapy
- Benetti Elisa (tutor prof. Simone Furini)
Title: Optimization of CNVs detection from WES data
- Mazziotta Francesco (tutor prof. Sara Galimberti)
Title: Deciphering T-cell differentiation landscape in patients with Acute Myeloid Leukemia after induction chemotherapy
- Simeone Irene (tutor prof. Andrea Galli)
Title: Metabolic reprogramming of hepatocellular carcinoma by oncogenic RuvBL1
- Daffinà Maria Grazia (tutor prof. Rolando Cimaz)
Title: The role of soluble CD-25 as a predictive biomarker in mesothelioma patients treated with immune-checkpoints inhibitors
April 8th, 2021 at 5pm
- Bottaro Maria (tutor prof. Antonio Giordano)
Title: Targeting mitochondrial folate metabolism for malignant mesothelioma treatment
- Maiorano Patrizia (tutor prof. Antonio Giordano)
Title: Adenosine Pathway a biomarker of response and/or an actionable to overcome "immune escape" of human tumors?
- Damato Angela (tutor prof. Antonio Giordano)
Title: Genetic and Clinical Analysis in Advanced Colorectal Cancer patients enrolled in the Phase II NIVACOR trial
- Salvadori Costanza (tutor prof. Paola Guglielmelli)
Title: Study of the role of circular RNA in patients with MPN
April 22nd, 2021 at 5pm
- Elefante Elena (tutor prof. Marta Mosca)
Title: Integrating patients reported outcomes, clinical data, and quality indicators to physician-driven data in the clinical management of chronic rheumatic diseases: the paradigm of Systemic Lupus Erythematosus
- De Paolo Raffaella (tutor dr. Laura Poliseno)
Title: Zebrafish models in melanoma research: analysis of coding and non-coding BRAF variants
- Pepe Sara (tutor dr. Barbara Stecca)
Title: The innate immune checkpoint CD47 is a novel target of the Hedgehog-GLI pathway
- Romagnoli Simone (tutor prof. Alessandro M. Vannucchi)
Title: Identification of Structural Variants in Acute Myeloid Leukemia with normal karyotype patients by using long reads sequencing technology
- Fortunato Diogo (tutor prof. Alessandra Renieri)
Title: Development of extracellular vesicle-targeting tools for novel liquid biopsy approaches in lung cancer
April 29th, 2021 at 5pm
- Dragoni Gabriele (tutor prof. Andrea Galli)
Title: The role of PAD4 in the pathogenesis of intestinal fibrosis in Crohn's disease
- D'Ignazio Alessia (tutor prof. Franco Roviello)
Title: The immunonutrition in gastrointestinal cancer patients: the microenvironment from a genotypic point of view
- Campoli Marco (tutor prof. Pietro Rubegni)
Title: Proactive sinecatechins for the treatment of cutaneous HPV related lesions
- Romagnoli Dario (tutor dr. Angelo Di Leo/Laura Biganzoli )
Title: Identification and development of epigenetic tumor biomarkers through computational biology approaches
- Livraghi Luca (tutor dr. Angelo Di Leo/Laura Biganzoli )
Title: Assessment of homologous recombination deficiency in breast cancer using methylation signatures
May 6th, 2021 at 5pm
- Sant'Antonio Emanuela (tutor prof. Alessandro M. Vannucchi)
Title: Understanding the genetic and epigenetic basis of JAK-inhibitor resistance
- Ciofini Sara (tutor prof. Monica Bocchia)
Title: New prognostic markers in acute myeloid leukemia: focus on PD1-PDL1 and Bcl2
- Zuanelli Brambilla Corrado (tutor prof. Monica Bocchia)
Title: Relapse after allogeneic stem cell transplantation of acute myeloid leukemia and myelodysplastic syndrome and importance of second cellular therapy
- Bindi Ilaria (tutor prof. Marco Mandalà)
Title: Non-syndromic hearing loss related to mutation of the PDE1C: our experience
- Trusso Maria Allegra (tutor prof. Andrea Fagiolini)
Title:Heritability of symptom clusters within families affected by psychiatric illness
May 20th, 2021 at 5pm
- Bruno Martina (tutor prof. Antonio Giordano)
Title: BAP1 promotes mesothelioma stem cell-like features though IP3R3-mediated mitochondrial calcium flux
- Costa Aurora (tutor prof. Antonio Giordano)
Title: Pharmacological reactivation of RBL2/p130 could be an effective antitumoral strategy for malignant pleural mesothelioma
- Baldanzi Caterina (tutor dr. Laura Poliseno)
Title: Identification of the molecular mechanisms by which pigmentation limits vemurafenib activity in melanoma cells
- Lombardi Zoe (tutor prof. Elisabetta Rovida)
Title: Optimization of ERK5 targeting in melanoma cell lines
June 10th, 2021 at 5pm
- Di Sarno Laura (tutor prof. Ilaria Meloni)
Title: MSCs application in bone and tendon regeneration
- Alaverdian Diana (tutor prof. Elisa Frullanti)
Title: Gene editing in epilepsy and mental retardation limited to females (EFMR)
- Bruno Lucia Pia (tutor prof. Alassandra Renieri)
Title: Exploring genetic bases of intellectual disability through exome sequencing analysis
- Beligni Giada (tutor prof. Francesca Ariani)
Title: CRISPR/Cas9 Gene editing approach for the correction of LRRk2 mutation in Parkinson disease
- Palomino Villcas Juan De Dios (tutor prof. Francesca Ariani)
Title: Identifying factors involved in extrachromosomal circular DNA biogenesis and clearance
- Lucchese Anna Maria (tutor prof. Antonio Giordano)
Title: Role of Pygo2 and canonical Wnt/β-Catenin signaling on mediating melanoma in the Zebrafish animal model
June 17th, 2021 at 5pm
- Capitani Chiara (tutor prof. Annarosa Arcangeli)
Title: Ion channels and transporters in breast cancer: promising targets of novel recombinant antibodies
- Chioccioli Altadonna Ginevra (tutor prof. Annarosa Arcangeli)
Title: Study and functional characterization of potassium channels network in the pancreatic ductal adenocarcinoma (PDAC) for innovative therapeutic strategies
- Frassineti Lorenzo (tutor prof. Claudia Manfredi)
Title: HRV analysis in newborns with seizures
- Barone Federica (tutor dr. Rosario Notaro)
Title: Modeling PNH hemolytic crisis associated with infection and inflammation
- Carriero Miriam Lucia (tutor prof. Ilaria Meloni)
Title: CRISPR/Cas9-based targeted genome editing for the treatment of CDKL5 deficiency disorder
June 23rd, 2021 at 5pm
- Pettini Francesco (tutor prof. Simone Furini)
Title: Free energy estimate of hERG block by Proton-Pump Inhibitors with molecular dynamics simulations
- Prantera Antonella (tutor dr. Laura Poliseno)
Title: Identification and characterization of proapoptotic targets of miR-204 in melanoma
- Inzalaco Giovanni (tutor dr. Mario Chiariello)
Title: Deciphering novel MAPK15 cellular functions by shotgun proteomics
- Lottini Giulia (tutor prof. Giulia Freer)
Title: Assessing the immune response to SARS-CoV-2 by immunofluorescence staining
- Zguro Kristina (tutor prof. Simone Furini)
Title: Molecular Dynamics simulations of ion conduction in the human sodium channel Nav 1.4
July 8th, 2021 at 5pm
- Mecaacci Bianca (tutor prof. Monica Bocchia)
Title:
- Gaggiano Carla (tutor prof. Luca Cantarini)
Title:
- Sota Jurgen (tutor prof. Luca Cantarini)
Title:
- Puzzono Marta (tutor prof. Andrea Galli)
Title:
- Guida Alice (tutor prof. Andrea Galli)
Title:
- Cavigli Luna (tutor prof. Flavio D'Ascenzi)
Title:
- Martellucci Ignazio (tutor prof. Marco Mandalà)
Title:
- Baldassarri Margherita (tutor prof. Francesca Mari)
Title:
July 25th, 2021 at 5pm
- Solmonese Laura (tutor prof. Michele Maio)
Title:
- Bianchi Francesco (tutor prof. Elena Bargagli)
Title:
- Vietri Lucia (tutor prof. Elena Bargagli)
Title:
- Menegazzi Giulio (tutor prof. Persio Dello Sbarba)
Title:
- Rosati Diletta (tutor prof. Antonio Giordano)
Title:
- Cersosimo Francesca (tutor prof. Antonio Giordano)
Title:
- Cartocci Alessandra (tutor prof. Pietro Rubegni/Gabriele Cevenini)
Title:
Progress report schedule, academic year 2018-2019
February 26th, 2019 at 1pm, Centro Didattico Le Scotte, room 9
- Nicolì Vanessa (tutor Prof. Migliore)
Title: "A study on epigenetic modifications in human placentas and buccal mucosa cells of newborns"
- Gallo Roberta (Tutor Prof. Coppedè)
Title: " Methylation analysis in girls with Autism Spectrum Disorders (ASD)
- Dapporto Francesca (Tutor Dr. Chiariello)
Title: "Role of MAPK15 protein in human tumors"
March 7th, 2019 at 1pm, Centro Didattico Le Scotte, room 6
- Bergantini Laura (Tutor Prof. Bargagli)
Title: "Idiopathic Pulmonary Fibrosis, serum proteomic analysis before and after nintedanib therapy"
- Fulco Beniamino (Tutor Prof. Giordano)
Title: "Preventive and antiproliferative effects of tomato extracts on colorectal cancer"
- Fui Annalisa (Tutor Prof. Bargagli)
Title: "Rituximab Therapy in Interstitial Lung Disease (ILD) associated with Rheumatoid arthritis"
April 19th, 2019 at 1pm, Centro Didattico Le Scotte, room 6
- Beltrami Matteo (Tutor prof. Nuti )
Title: "Multimodality imaging in cardiomyopathies: correlation with genetic and pathological substrates, functional capacity, prognostic stratification and virtual modeling"
- Anichini Giulia (Tutor Prof. Stecca )
Title: "The role of the Hedgehog pathway in cholangiocarcinoma"
- Ferrigno Ilaria (Tutor Prof. Bocchia)
Title: "Prognostic role of Isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) mutations in Acute Myeloid Leukemia"
May 17th, 2019 at 1pm, Centro Didattico Le Scotte, room A
- Dell'Aquila Milena (Tutor Prof. Giordano)
Title: "Phosphoproteomic screening reveals the multiple functions of cdk9 in dna damage response "
- D'Angelo Costantino (Tutor Prof. Giordano)
Title: "Evaluation of anti-proliferative and antioxidant potential of tomatoes extracts against melanoma"
- Bonetti Justine (Tutor Dr. Conticello)
Title: "Therapeutic potential of S-nitrosothiols in the prevention of atherosclerosis: Modulation of monocytes and smooth muscle cells metaplasia into foam cells"
May 21th, 2019 at 1pm, Centro Didattico Le Scotte, room 13
- Tarantino Danilo (Tutor Dr. Conticello)
Title: "The weight of APOBEC mutations in cancer development"
- Martignano Filippo (Tutor Dr. Conticello)
Title: "Third generation sequencing: liquid biopsy applications"
- Cannito Sara (Tutor Prof. Maio)
Title:
- Farhad Jahanfar (Tutor Prof. Arcangeli)
Title: "High-throughput screening of analgesic compounds"
June 19th, 2019 at 1pm, Centro Didattico Le Scotte, room 11
- Lembo Gaia (Tutor Dr. Conticello)
Title: "Drugging the mutators: Design of inhibitors of APOBECs"
- Palmieri Maria (Tutor Dr. Frullanti)
Title: "Cell free-DNA pinpoints specific clonal expansion at disease in solid cancers"
June 25th, 2019 at 1:30pm, Centro Didattico Le Scotte, room 14
- Croci Susanna (Tutor Dr. Meloni)
Title:
-Lorenzetti Flaminia (Tutor Prof.ssa Mari)
Title:
Progress report schedule, academic year 2017-2018
11th January 2018 at 15.00 - Centro Didattico Le Scotte, Room 6
- Barsotti Simone (Mosca)
Title: "Effects of hydroxychoroquine supplementation on mesenchymal stromal cells in an animal model of Systemic Lupus Erythematosus (SLE): preliminary results and further prospective"
- De Palma Anna (Galeazzi-Fioravanti)
Title: "Hydrostatic Pressure Regulates MicroRNA Expression Levels in Osteoarthritic Chondrocyte Cultures via the Wnt/β-Catenin Pathway"
- Beltrami Matteo (Nuti)
Title: "Multimodality imaging in cardiomyopathies: correlation with genetic and pathological substrates, functional capacity, prognostic stratification and virtual modelling"
22th January 2018 at 15.00 - Centro Didattico Le Scotte, Room 6
- Tubita Alessandro (Dello Sbarba)
Title: "Targeting the Mitogen-Activated Protein Kinase ERK5 in human melanoma"
- Lamberti Arianna (Fimiani)
Title: "Molecular evolution of cutaneous cd30 positive lymphoproliferative disorders: pathogenetic and clinical implications"
- Anichini Giulia (Stecca)
Title: "Deconstructing the molecular program induced by SOX2 and GLI1"
5th February 2018 at 15.00 - Centro Didattico Le Scotte, Room 6
- Montini Marco (Conticello)
Title: "Assaying the order of events in cells through CRISPR/Cas9"
- Chieca Martina (Conticello)
Title: "Dimerization of APOBEC1 is dispensable for RNA editing"
- Di Giorgio Salvatore (Conticello)
Title: "APOBEC1-dependent RNA editing, a bioinformatics approach"
- Donati Francesco (Conticello)
Title: "APOBEC1 mutants to assess RNA and DNA editing component in cancer"
12th February 2018 at 15.00 - Centro Didattico Le Scotte, Room 6
- Iorio Jessica (Arcangeli)
Title: "Functional relationships between ion channels and pH-regulating mechaninsms in colorectal cancer"
- Antonuzzo Lorenzo (Arcangeli)
Title: "Expression and prognostic significance of hERG1 in Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs)"
- Cesari Daniele (Giordano A)
Title: "PRMT5 as two-in-one strategy for mesothelioma treatment"
- Cosi Irene (De Angioletti)
Title: "Transcriptional regulation and oncogenic effects of the genes deregulated by the prostate-specific expression of ETV4"
21th February 2018 at 15.00 - Centro Didattico Le Scotte, Room 6
- Grassi Susanna (Galimberti)
Title: "Pharmacogenomic, epigenetic, proteomic, and immunological variables as possible predictive markers of response and toxicity in patients affected by chronic myeloid leukemia (CML) receiving tyrosin kinase inhibitors (TKIs)"
- Antonuzzo Lorenzo (Arcangeli)
Title: "Expression and prognostic significance of hERG1 in Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs)"
- Brogi Alice (Santini)
Title: "Mechanisms of resistance to hypomethylating agents in MDS/AML syndromes"
- Poteti Martina (Dello Sbarba)
Title: "The metabolic profile of Chronic Myeloid Leukaemia (CML) stem cell subsets as a target to suppress minimal residual disease resistant to tyrosine kinase inhibitors"
- Lorenzetti Flaminia Clelia (Renieri)
Title:
9th March 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Corbizi Fattori Giuditta (Vannucchi)
Title: "Exploiting mutated CALR for diagnostic, prognostic and therapeutic purposes in MPN"
- Fanelli Tiziana (Vannucchi)
Title: "Clonal heterogeneity and clonal progression in the leukemic transformation of chronic myeloproliferative neoplasms"
- Materozzi Maria (Nuti)
Title: "Molecular biology of Paget’s Disease of Bone: role of p62 and novel genes"
- Croci Susanna (Giannotti)
Title: "cell therapy and scaffolds in chondral and osteochondral injuries" / "FOXG1 gene therapy using CRiSPR/Cas9 technology and AVV9 system i iPSCs-derived neurons"
22th March 2018 or 4th April 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Stoccoro Andrea (Migliore)
Title: "Mitochondrial DNA methylation in neurodegenerative diseases"
- Nicolì Vanessa (Migliore)
Title: "Environmental factors of prenatal risk: a study of epigenetic modification in human placentas and buccal mucosa cells of newborns"
- Gallo Roberta (Migliore)
Title: "Methylation analysis in girls with Autistic Spectrum Disorders (ASD)"
- Guarnieri Giulia (Vannelli)
Title: "Study of the genetic and epigenetic mechanisms regulating neurogenesis in human cholinergic neurons"
11th April 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Cannito Sara (Maio)
Title: "Modeling of cancer immune phenotype by new epigenetic drugs: a strategy to improve efficacy of immunotherapy"
- Monterisi Santa (Maio)
Title: "Immune-remodeling activity of epigenetic drugs as base for novel combinatorial immunotherapy clinical trials for cancer patients"
- D'Angelo Costantino (Giordano A)
Title:
- Fulco Beniamino (Giordano A)
Title: "The impact of genetic variation on nutrients metabolism can help to identify risk for cancer progression"
23th April 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Ferrigno Ilaria (Bocchia)
Title: "Prognostic role of isocitrate dehydrogenase 1 and 2 (IDH1/IDH2) mutations in Acute Myeloid Leukemia"
- Fui Annalisa (Rottoli)
Title: "Biomarkers analysis, clinical-radiological characterization and response to biologic therapy of patients with Interstitial lung diseases with Autoimmune Disorders of Connective Tissue"
- Bergantini Laura (Rottoli)
Title:
- Valentini Maria Lucia (Rottoli)
Title:
11th May 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Mori Elena (Di Leo)
Title: "Serum metabolomic profiles (smps) for discriminating early from metastatic disease and predicting relapse in patients (pts) with crc"
- Laera Letizia (Di Leo)
Title: "Exploratory investigation of serum metabolomics as predictive biomarkers of response to checkpoint inhibitors in patients with advanced non-small-cell lung cancer (NSCLC)"
- Vitale Stefania (Di Leo)
Title:
- Palmieri Maria (Frullanti)
Title: "Identification of genetic bases of individual predisposition to lung cancer in non-smokers"
16th May 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Finizola Francesco (Laghi Pasini)
Title: "Systemic inflammation as a novel QT-prolonging risk factor"
- Leonardi Margherita (Chiariello)
Title: "Screening of a library of activated Kinases identifies the IKBKE Oncogene as a positive regulator of the Autophagic process"
- Dapporto Francesca (Chiariello)
Title:
- Tognetti Linda (Fimiani)
Title: "Clinical and laboratory characterization of patients with cutaneous sclerosing disorders and response to UVA-1 and extracorporeal photochemotherapy: in vivo and in vitro skin models"
31th May 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Astarita Carlo (Giordano A)
Title: "Hormone imbalance causes aberrant PAI-2 and pRb2/p130 function promoting eye disease"
- Menicacci Beatrice (Del Rosso)
Title: "Chronic treatment with resveratrol and olive oil phenols on MRC5 fibroblast SASP: inhibition of pro-tumoral microenvironment"
- Altieri Angela (Giordano A)
Title: "Development of new technologies for identification of a novel proteins involved in the DNA damage response (DDR)"
- Dell'Aquila Milena (Giordano A)
Title: "Identification of hnRNPD protein interactions in response to DNA damaging agents"
11th June 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Gelli Elisa (Ariani)
Title: "Evidences of constitutive promoter hypermethylation in Retinoblastoma"
- Daga Sergio (Mari)
Title: "CRiSPR/Cas9 gene therapy on urine-derived-podocytes-like cells: a new perspective in treatment of ATS"
- Catania Lorenza Maria (Renieri)
Title: "Disturbance of GABA-ergic transmission in FOXG1 neurons"
- Paganini Irene (Papi)
Title: "Identification of novel schwannomatosis genes through exome sequencing"
June or July 2018 at 15.00 - Centro Didattico Le Scotte, Room
- Taratino Danilo (Conticello)
Title: "Evidences of constitutive promoter hypermethylation in Retinoblastoma"
- Martignano Filippo (Conticello)
Title:
- Lembo Gaia (Conticello)
Title:
Progress report schedule,academic year 2016-2017
20th July 2017 at 14.00 - Centro Didattico Le Scotte, Room 9
- Tubita Alessandro (Dello Sbarba)
Title: "Targeting the Mitogen Activated-Protein Kinase ERK5 in human melanoma"
- Poteti Martina (Dello Sbarba)
Title: "The metabolic profile of Chronic Myeloid Leukaemia stem cell subsets as a target to suppress treatment-resistant minimal residual disease"
- Antonuzzo Lorenzo (Arcangeli)
Title: "Expression and prognostic significance of hERG1 in gastroenteropancreatic neuroendocrine neoplasms"
12th July 2017 at 14.00 - Centro Didattico Le Scotte, Room 6
- Stoccoro Andrea (Migliore)
Title: "Mitochondrial DNA methylation in neurodegenerative diseases"
- Guarnieri Giulia (Vannelli)
Title: "Study of genetic and epigenetic mechanisms regulating neurogenesis in human cholinergic neurons"
- Gelli Elisa (Ariani)
Title: "Hereditary breast and ovarian cancer: characterization of new BRCA1/BRCA2 variants inducing splicing pattern perturbations"
- Paganini Irene (Papi)
Title: "Identification of novel schwannomatosis genes through exome sequencing"
5th July 2017 at 14.30 - Centro Didattico Le Scotte, Room 13
- Iorio Jessica (Arcangeli)
Title: "Functional relationships between K+ channels and pH-regulating mechanisms in colorectal cancer"
- Materozzi Maria (Nuti)
Title: "Molecular biology of Paget’s Disease of Bone: role of p62 and novel genes"
- Lamberti Arianna (Fimiani)
Title: "Genetic and molecular aspects of cutaneous anaplastic T-cell lymphoma"
28th June 2017 at 14.00 - Centro Didattico Le Scotte, Room 6
- Landucci Elisa (Renieri)
Title: "Modeling Rett syndrome with iPSCs-derived neurons"
14th June 2017 at 14.00 - Room within Library of Medical Biotechnologies Department - 3° Floor 2° lot
- Daga Sergio (Mari)
Title: "Urine-derived podocytes-like cells as diagnostic and therapeutic tool in Alport syndrome"
- Pinto Anna Maria (Renieri)
Title: "RNA-seq analysis of amniotic fluid Alport patient-derived podocytes reveals a generalized disruption of extracellular matrix genes along with overexpression of inflammatory cytokines"
- Finizola Francesco (Laghi Pasini)
Title: "Systemic inflammation as a novel QT-prolonging risk factor"
- Sarti Samantha (Poliseno)
Title: "Assessing the biological role of miR-204 in a zebrafish melanoma model"
12th May 2017 at 14.00 - Centro Didattico Le Scotte, Room 10
- Simone Barsotti (Mosca)
Effects of hydroxychoroquine and 25-OH vitamin D supplementation on mesenchymal stromal cells and endothelial function in an animal model of Systemic Lupus Erythematosus (SLE)
- Anna De Palma (Galeazzi, Fioravanti)
MicroRNAs expression after Cyclic Hydrostatic Pressure in human normal and osteoarthritic chondrocyte cultures
- Susanna Grassi (Galimberti)
Pharmacogenomic, epigenetic and proteomic variables as possible predictive markers of response and toxicity in patients affected by chronic myeloid leukemia (CML) receiving tyrosin kinase inhibitors (TKIs).
18th April 2017 at 14.00 - Centro Didattico Le Scotte, Room 6
- Altieri Angela (Giordano A)
Developement of new thecnologies for identification of Novel proteins involved in DNA damage response
6th April 2017 at 14.00 - Centro Didattico Le Scotte, Room 10
- Giacobini Gianluca (Maio)
Title: Identification of immune correlates of clinical activity and/or disease outcome in melanoma patients undergoing targeted therapy
- Lofiego Maria Fortunata (Maio)
Title: A new human cell-based vaccine for cancer therapy: pre-clinical characterization
- Tognetti Linda (Fimiani)
Title: Clinical and laboratory characterization of patients with sclerosing cutaneous disorders and response to UVA-1 phototherapy and extracorporeal photochemotherapy: in vitro and in vivo skin models
31st March 2017 at 14.00 - Centro Didattico Le Scotte, Room 6
- Mori Elena (Dello Sbarba - Di Leo)
Title to be defined
- Vitale Stefania (Dello Sbarba - Di Leo)
Title to be defined
- Laera Letizia (Francini - Di Leo)
Title to be defined
- Cesari Daniele (Giordano)
Title: "PRMT5 inhibition as multifaceted strategy in cancer treatment"
- Altieri Angela (Giordano)
Title: "DEVELOPEMENT OF NEW TECHNOLOGIES FOR IDENTIFICATION OF NOVEL PROTEINS INVOLVED IN DNA DAMAGE RESPONSE"
22th March 2017 at 14.00
- Corbizi Fattori Giuditta (Vannucchi)
Title: "Exploiting mutated calreticulin for diagnostic prognostic and therapeutic purposes in chronic myeloproliferative neoplasms"
- Fanelli Tiziana (Vannucchi)
Title: "Clonal heterogeneity and clonal progression in the leukemic transformation of chronic myeloproliferative neoplasms"
- Brogi Alice (Santini)
Title: "Mechanisms of resistance to hypomethylating agents in MDS/AML syndromes"
- Cencini Emanuele (Bocchia)
Title: "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with non-Hodgkin lymphomas"
- Candi Veronica (Bocchia)
Title: "Next Generation flow cytometry for detecting minimal residual disease in multiple myeloma patients"
27th February 2017 at 14.00 - Seminar Room Building 27, Core Research Laboratory ITT, Viale Pieraccini, 6 - Firenze
- Montini Marco (S. Conticello)
Title: "Assaying the order of events in cell throught CRISPR/Cas9"
- Chieca Martina (S.Conticello)
Title: "Impact of APOBEC1 mediated RNA editing in Retinoblastoma tumor suppressor protein"
- Di Giorgio Salvatore (S.Conticello)
Title: "Apobec dependent una editing, a bioinformatic approach"
- Donati Francesco (S.Conticello)
Title: "Assessing the mutagenic activity of APOBEC1 mutants"
6th February 2017 at 14.00 - Centro Didattico Le Scotte, Room 9
- Menicacci Beatrice (M. Del Rosso)
Title: "Senescence secretory phenotype and tumor microenvironment: modulation by polyphenolic compounds"
- Leonardi Margherita (M. Chiariello)
Title: "IKBKE oncogene upregulates autophagy in breast cancer"
- Cosi Irene (M. De Angioletti)
Title: "Establishment of primary prostate cell lines from transgenic mice: a tool to study prostate specific genetic alterations"
- Mancuso Pietro (A. Giordano)
Title: "Role of TDG in DNA demethylation and transcriptional regulation in melanoma"
30th November 2016 at 13:00 - Centro Didattico Le Scotte, Room 6
- Astarita Carlo (A. Giordano)
Title: "Hormone Imbalance Promotes Eye Disease Through Chronic Cellular Stress"
- Delaram Rahmani (A. Giordano)
Title: "Novel insight of Pyrvinium Pamoate anti-cancer activity: a study on mesothelioma"
Progress report schedule, academic year 2014-2015
June 26, 2015 - Centro Didattico Le Scotte, 13.00-14.00 – Room 4
-Pinto Anna Maria (A. Renieri): "Molecular basis of Arteriovenous Malformations (AVMs)"
-Giacobini Gianluca (M. Maio): "Identification of immune correlates of clinical activity and/or disease outcome in melanoma patients undergoing immunotherapy or targeted therapy"
-Lofiego Maria (M. Maio): "A new human cell-based vaccine for cancer therapy: pre-clinical characterization"
June 17, 2015 - Centro Didattico Le Scotte, 12.00-13.00 – Room 13
-Delaram Rahmani (A. Giordano): "The role of cell cycle regulators in human cancer"
-Landucci Elisa (A. Renieri): "Modeling Rett syndrome with iPSCs-derived neurons"
-Mancuso Pietro (A. Giordano – A. Bellacosa): "Role of TDG in DNA demethylation and transcriptional regulation in melanoma"
-Sarti Samantha (L. Poliseno): "New approaches for the identification and the study of pseudogenes in melanoma"
June 8, 2015 - Centro Didattico Le Scotte, 14.00-15.00 – Room 6
-Cencini Emanuele (M. Bocchia): "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with non-Hodgkin lymphomas"
May 19, 2015 - Centro Didattico Le Scotte, 12.00-13.30 – Room 6
-Imperatore Valentina (A. Renieri): "Massive parallel sequencing in sporadic retinoblastoma patients reveals somatic mosaicism"
-Lopomo Angela (L. Migliore): "Genetic and epigenetic biomarkers in myasthenia gravis"
-Penon Antonella (A. Giordano): "Study of the role of various tomato cultivars in colorectal cancer development"
May 12, 2015 - Centro Didattico Le Scotte, 12.00-13.00 – Room 14
-Cheleschi Sara (A. Fioravanti, M. Galeazzi): "Possible chondroprotective effect of canakinumab: an in vitro study on human osteoarthritic chondrocytes"
-Chiarucci Carla (M. Maio): "Identification of immune-related biomarkers that can be predictive for clinical responses to targeted therapies in melanoma patients"
-Fazio Carolina (M. Maio): "Pre-clinical development of new combined epigenetic and immunotherapeutic approaches for (the treatment of ) malignant mesothelioma"
-Iannuzzi Carmelina (A. Giordano): "Dissecting the molecular mechanisms underlying mesotelioma development and progression"
May 8, 2015 - Centro Didattico Le Scotte, 12.00-13.00 – Room 14
-Cutaia Ornella (M. Maio): "Recognition of melanoma associated antigens and HLA-matched melanoma cell lines by PBMCs from metastatic melanoma patients in the course of immunotherapy with immune checkpoint blockade agents"
-Belcastro Eugenia (A. Pompella): "Inflammation and denitrosating enzymes: from the development of a cellular inflammatory model to pathological tissues"
-Bennett David (P. Rottoli): "Research of clinical biomarkers with diagnostic and prognostic meaning in patients with interstitial lung diseases and lung transplant"
-Caporaso Antonella (A. Giordano): "Identification of novel CDK9-55 kDa substrates involved in DNA damage response"
April 29, 2015 - Centro Didattico Le Scotte, 13.00-14.00 – Room 14
-Ciabatti Elena (S. Galimberti): "Myelodysplastic syndromes: a multidisciplinary integrated diagnostic work-up for patients’ risk stratification"
-Della Latta Veronica (M.A. Morales): "Adenosine modulation in the process of cardiopulmonary fibrosis. Bio-molecular characterization of receptor subtypes at tissue and peripheral level"
-Magnotti Flora (M. Galeazzi): "Role of neutrophils activation in the pathogenesis of systemic juvenile idiopathic arthritis"
-Aprile Lara (M. Bocchia): "Increased atherothrombotic risk and nilotinib treatment in chronic myeloid leukemia patients: a probable role for genetic predisposition and induced pro-inflammatory/pro-oxidative status"
April 15, 2015 - Centro Didattico Le Scotte, 13.00-14.00 – Room 14
-Bianciardi Laura (F. Ariani): "Set up whole exome sequencing"
-Blagojevic Jelena (M. Matucci Cerinic): "Role of pleiotrophin and midkine in systemic sclerosis"
-Gentile Daniela (F. Laghi Pasini): "Expression and function of the P2X7 receptor in dermal fibroblasts from patients with Systemic Sclerosis"
-Carli Linda (M. Mosca): "Urinary biomarkers in the differential diagnosis between lupus nephritis and pre-eclampsia: preliminary data"
Lab meeting schedule, academic year 2013-2014
June 17, 2014- Centro Didattico Le Scotte, 16.00-18.00
"Experimental protocol for non-invasive analysis of maternal plasma" - Imperatore Valentina (XXIX cycle, tutor: A. Renieri)
"FOXG1 impact on adult brain in congenital Rett syndrome" - Amabile Sonia (XXVII cycle, tutor: F. Mari)
"Evaluation of serum levels of some adipokines in patients with chronic inflammatory joint diseases before and after treatment with biologics" - Cheleschi Sara (XXIX cycle, tutor: A. Fioravanti, M. Galeazzi)
"Role of neutrophils activation in the pathogenesis of systemic juvenile idiopathic arthritis" - Magnotti Flora (XXVIII cycle, tutor: M. Galeazzi)
"Evaluation of the potential anticancer activity of a RB2-derived small molecule on glioblastoma cell line" - Napoliello Luca (XXVII cycle, tutor: A. Giordano)
June 5, 2014- Centro Didattico Le Scotte, 16.00-18.00
"Dissecting the molecular mechanisms underlying mesotelioma development and progression" - Iannuzzi Carmelina (XXIX cycle, tutor: A. Giordano)
"Identification of novel CDK9-55 kDa substrates involved in DNA damage response" - Caporaso Antonella (XXIX cycle, tutor: A. Giordano)
"Study of the role of mediterranean diet in colorectal cancer prevention and in a possible supporting strategy of chemiotherapy" - Penon Antonella (XXIX cycle, tutor: A. Giordano)
"Identification of immune-related biomarkers that can be predictive for clinical responses to immunomodulating agents and /or targeted therapies in melanoma and mesothelioma patients" - Carla Chiarucci (XXIX cycle, tutor: M. Maio)
"Pre-clinical development of new combined epigenetic and immunotherapeutic approaches for (the treatment of ) malignant mesothelioma" - Fazio Carolina (XXIX cycle, tutor: M. Maio)
May 22, 2014- Centro Didattico Le Scotte, 16.00-18.00
"Research of clinical biomarkers with diagnostic and prognostic meaning in patients with interstitial lung diseases and lung transplant" - Bennett David (XXIX cycle, tutor: P. Rottoli)
"Peripheral Arterial Occlusive Disease (Paod) is still an unexplained side effect in CML patients treated with Tyrosine Kinase Inhibitors: study of possible mechanisms underlining this adverse event" - Aprile Lara (XXIX cycle, tutor: M. Bocchia)
"Genetic and epigenetic biomarkers in myasthenia gravis" - Lopomo Angela (XXIX cycle, tutor: L. Migliore)
"Circulating tumor markers: predictors of incomplete cytoreduction and powerful determinants of outcome in peritoneal carcinomatosis of colorectal origin" - Cioppa Tommaso (XXIX cycle, tutor: F. Roviello)
"Urinary biomarkers in lupus nephritis: preliminary data" - Carli Linda (XXVIII cycle, tutor: M. Mosca)
May 6, 2014- Centro Didattico Le Scotte, 16.00-18.00
"Genetics and tolerance of virtual reality distraction intervention in cancer patients" - Milanese Carla (XXVII cycle, tutor: A. Giordano)
"Adenosine modulation in the process of cardiopulmonary fibrosis. Bio-molecular characterization of receptor subtypes at tissue and peripheral level" - Della Latta Veronica (XXVIII cycle, tutor: M.A. Morales)
"Expression and function of the P2X7 receptor in dermal fibroblasts from patients with Systemic Sclerosis" - Gentile Daniela (XXVIII cycle, tutor: F. Laghi Pasini)
"Identification of new oncogenes involved in the autophagic process" - Merelli Eva (XXVIII cycle, tutor: M. Chiariello)
April 15, 2014 - Centro Didattico Le Scotte, 16.00-18.00
"Identification of new disease genes involved in nephropaties" - Bianciardi Laura (XXVIII cycle, tutor: F. Ariani)
"Characterization of lower limb cutaneous ulcers in systemic sclerosis: the analysis of 554 lesions" - Blagojevic Jelena (XXVIII cycle, tutor: M. Matucci Cerinic)
"New molecular markers for the screening of myelodysplastic syndromes" - Ciabatti Elena (XXVIII cycle, tutor: S. Galimberti)
"Characterization of the phenotypic responses in metastatic melanoma patients in the course of immunotherapy with anti-CTLA-4 blockade" - Cutaia Ornella (XXVIII cycle, tutor: M. Maio)
"Synaptic Changes associated with CDKL5 mutations" - Patriarchi Tommaso (XXVII cycle, tutor: A. Renieri)
April 4, 2014 - Centro Didattico Le Scotte, 16.00-18.00
"Mutational study of p53 in patients with Relapsed/Refractory Multiple Myeloma" - Lucani Benedetta (XXVII cycle, tutor: M. Bocchia)
"The role of immuno-monitoring as predictive marker in metastatic melanoma patients treated with different immunotherapy regimens" - Danielli Riccardo (XXVII cycle, tutor: M. Maio)
"Prognostic potential of epigenetic markers in cutaneous melanoma" - Parisi Giulia (XXVII cycle, tutor: M. Maio)
"Alteration of aortic constituents in thoracic aortic aneurysm and role of MMPs, TIMPs and GGT in the pathogenesis of the disease" - Gazaneo Sara (XXVII cycle, tutor: P. Tanganelli)
March 25, 2014 - Centro Didattico Le Scotte, 16.00-18.00
"The role of haematological markers in patients undergoing thymectomy: a study from United Kingdom" - Granato Felice (XXVI cycle, tutor: S. Civitelli)
"Role of cross-talk between platelets and lympho-monocytes in tissue repair and wound healing" - Nami Niccolò (XXVII cycle, tutor: M. Fimiani)
"APOBEC1: a possible role in melanoma growth and stemness" - Pietrobono Silvia (XXVII cycle, tutor: B. Stecca, S. Conticello)
"Experimental evaluation of computationally designed peptides with high affinity for a target protein" - Russo Anna (XXVII cycle, tutor: A. Giordano)
"Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment" - Ruvio Martina (XXVII cycle, tutor: R. Nuti)
February 20, 2014 - Centro Didattico Le Scotte, 16.00-18.00
"Possible protective role of some Mediterranean diet foods in relation to cancer" - Barone Daniela (XXVII cycle, tutor: A. Giordano)
"New pyrazolo[3,4-d]pyrimidine SRC inhibitors as potential candidates for malignant astrocytomas therapy" - Ceccherini Elisa (A. Giordano)
February 4, 2014 - Centro Didattico Le Scotte, 16.00-18.00
"Role of KRAS mutation as predictor of pathologic response after neoadjuvant chemoradiation therapy for rectal cancer" - Martellucci Jacopo (XXVI cycle, tutor: S. Civitelli)
"Hereditary breast and ovarian cancer" - Mencarelli Maria Antonietta (XXVI cycle, tutor: A. Renieri)
"Estrogens promote tumor formation by inducing hypoxia" - Rizzo Valeria (XXVI cycle, tutor: A. Giordano)
"Proteomic approach to characterize Idiopathic Pulmonary Fibrosis and its different clinical phenotypes" - Carleo Alfonso (XXVII cycle, tutor: P. Rottoli)
January 21, 2014- Centro Didattico Le Scotte, 16.00-18.00
"New strategies for the treatment of rhabdomyosarcoma" - Casini Nadia (XXVI cycle, tutor: A. Giordano)
"Unbiased Next Generation Sequencing analysis confirms the existence of autosomal dominant Alport syndrome in a relevant fraction of cases" - Fallerini Chiara (XXVI cycle, tutor: F. Mari)
Lab meeting schedule, academic year 2012-2013
13 June 2013 - Room 7, Centro Didattico, 16.00-18.00
"Mutational study of P53 in patients with multiple myeloma relapsed / refractory" - Lucani Benedetta (XXVII ciclo, tutor: M. Bocchia)
"Adenosine modulation in the process of cardiopulmonary fibrosis. Bio-molecular characterization of receptor subtypes at tissue and peripheral level" - Della Latta Veronica (XXVIII ciclo, tutor: A. Morales)
"Expression and function of the P2X7 receptor in dermal fibroblasts from patients with Systemic Sclerosis" - Gentile Daniela (XXVIII ciclo, tutor: F. Laghi Pasini)
"Role of neutrophils activation in the pathogenesis of systemic juvenile idiopathic arthritis" - Magnotti Flora (XXVIII ciclo, tutor: M. Galeazzi)
"Setup of a system for the evaluation of cellular autophagy" - Merelli Eva (XXVIII ciclo, tutor: M. Chiariello)
30 May 2013 - Room 9, Centro Didattico, 16.00-18.00
"Identification of new disease genes involved in nephropaties" - Bianciardi Laura (XXVIII ciclo, tutor: F. Ariani)
“Characterization of Lower Limb Cutaneous Lesions in Systemic Sclerosis: the Analysis of 424 Lesions” - Blagojevic Jelena (XXVIII ciclo, tutor: M. Matucci Cerinic)
“Urinary proteomic biomarkers in lupus nephritis: preliminary data” - Carli Linda (XXVIII ciclo, tutor: M. Mosca)
"Molecular markers for diagnosis and prognosis of patients affected by myelodisplastic syndromes" - Ciabatti Elena (XXVIII ciclo, tutor: S. Galimberti)
“Characterization Of The Humoral Responses In Patients With Advanced Metastatic Melanoma In The Course Of Immunotherapy With Anti-Ctla-4 Blockade” - Cutaia Ornella (XXVIII ciclo, tutor: M. Maio)
14 May 2013 - May 14, 2013- Room 11, Centro Didattico, 16.00-18.00
"Alteration of aortic constituents in thoracic aortic aneurysm and role of MMPs,TIMPs and GGT in the pathogenesis of the disease" - Gazaneo Sara (XXVII ciclo, tutor: P. Tanganelli)
"Possible protective role of some Mediterranean diet foods in relation to gastric cancer: inside molecular pathways" - Barone Daniela (XXVII ciclo, tutor: A. Giordano)
"Role of APOBEC1 in melanoma stemness" - Pietrobono Silvia (XXVII ciclo, tutor: B. Stecca)
“Computational studies and experimental evaluation of high affinity peptide-protein interactions” - Russo Anna (XXVII ciclo, tutor: A. Giordano)
“Long-term bone density evaluation in cerebrotendinous xanthomatosis: evidence of improvement after chenodeoxycholic acid treatment” - Ruvio Martina (XXVII ciclo, tutor: R. Nuti)
"Synaptic changes associated with CDKL5 mutation" - Patriarchi Tommaso (XXVII ciclo, tutor: A. Renieri)
23 April 2013 - Room 10, Centro Didattico, 17.00-19.00
- New pyrazolo[3,4-d]pyrimidine SRC inhibitors as potential candidates for malignant astrocytomas therapy (Ceccherini Elisa, XXVII ciclo, tutor: A. Giordano)
- Genetics and tolerance of virtual reality distraction intervention in cancer patients (Milanese Carla, XXVII ciclo, tutor: A. Giordano)
- Role of cross-talk between platelets and leucocytes in skin repair and in immune-mediate diseases (Nami Niccolò, XXVII ciclo, tutor: M. Fimiani)
- Evaluation of the potential anticancer activity of a RB2-derived small molecule on glioblastoma cell line (Napoliello Luca, XXVII ciclo, tutor: A. Giordano)
- Prognostic potential of Epigenetic markers in cutaneous melanoma (Parisi Giulia, XXVII ciclo, tutor: M. Maio)
27 March 2013 - Room 9, Centro Didattico, 16.00-18.00
"22q11.2 micro-deletion and MURCS association syndrome" - Amabile Sonia (XXVII ciclo, tutor: F. Mari)
"Proteomic Analysis of BronchoAlveolar Fluid Lavage in patients with Idiopathic Pulmonary Fibrosis" - Carleo Alfonso (XXVII ciclo, tutor: P. Rottoli)
"The role of immuno-monitoring as predictive marker in metastatic melanoma patients treated with DACARBAZINE AND THYMOSIN ALFA 1 within an expanded access program (EAP)" - Danielli Riccardo (XXVII ciclo, tutor: M. Maio)
Lab meeting schedule, academic year 2011-2012
1 August 2012 h 16.30 - 19.30 room 15 San Miniato
- New pyrazolo[3,4-d] pyrimidine SRC inhibitors as potential candidates for malignant astrocytoma therapy (Elisa Ceccherini, Oncological Genetics, XXVII cycle, tutor: A. Giordano)
- Genetics of Retinoblastoma predisposition (Moen Riaz, Medical Genetics, XXVII cycle, tutor: A. Renieri)
- New strategies for the study and treatment of rhabdomyosarcoma (Nadia Casini, Oncological Genetics, XXVI cycle, tutor: A. Giordano)
- 22q11.2 micro-deletion and MURCS association syndrome: mutation in non-deleted allele as a possible cause of MURCS association phenotype (Sonia Amabile, Medical Genetics, XXVII cycle, tutor: A. Renieri)
- Targeting the checkpoint kinase WEE1 for cancer therapy (Eleonora Marcelli, Experimental Medicine and Atherosclerosis, XXVI cycle, tutor: P. Tanganelli)
- A Novel Role for Relaxin (RLX) and its Receptor (LGR7) in Limited Systemic Sclerosis (lSSc) (Claudio Corallo, Osteo-Metabolic Diseases, XXVI cycle, tutor: N. Giordano)
- The role of surgical lung biopsy in the management of undefined parenchymal lung disease (Felice Granato, Hepathobiliopancreatic Diseases and Multitumoral Syndromes, XXVI cycle, tutor: S. Civitelli)
- Synaptic changes associated with CDKL5 mutations (Tommaso Patriarchi, Medical Genetics, XXVII cycle, tutor: A. Renieri) Videoconference from the University of California, Davis
- CSF microRNAs in HIV-associated neurological disorders (Marco Pacifici, Oncological Genetics, XXIV cycle, tutor: A. Giordano) Videoconference from LSU Health Sciences Center, New Orleans
18 July 2012 h 16.30 - 19.30 room 15
- Identification of human ANP amyloid in young patients affected by Congestive Heart Failure (Sara Gazaneo, Experimental Medicine and Atherosclerosis, XXVII cycle, tutor: P. Tanganelli)
- APOBEC-1: a possible role in cancer stemness? (Silvia Pietrobono, Oncological Genetics, XXVII cycle, tutor: B. Stecca)
- Evaluation of the potential anticancer activity of a RB2-derived small molecule on malignant glioblastoma cell line (Luca Napoliello, Oncological Genetics, XXVII cycle, tutor: A. Giordano)
- Synthesis and biofunctionalization of gold nanoparticles: excellent drug-carrier and diagnostic tools (Anna Russo, Oncological Genetics, XXVII cycle, tutor: A. Giordano)
- The Role of Platelet-Rich Plasma in Tissue Regeneration (Stefania Mei, Clinical and Experimental Allegology and Immunology, XXVII cycle, tutor: M. Fimiani)
- The role of immuno-monitoring as predictive marker in metastatic melanoma patients treated with different immunotherapy regimens (Riccardo Danielli, Clinical and Experimental Allegology and Immunology, XXVII cycle, tutor: M. Maio)
- Laparoscopic total mesorectal excision for rectal cancer: long-term
results (Iacopo Martellucci, Hepatobiliopancreatic Diseases and Multitumoral Syndromes, XXVI cycle, tutor: S. Civitelli)
4th July 2012 h 16.30- 19.30 room 3
- Genetics and tolerance of virtual reality distraction intervention in cancer patients (Carla Milanese, Oncological Genetics, XXVII cycle, tutor: A. Giordano)
- Study of cross-talk between mononuclear cells and platelets in the pathogenesis of moderate-severe psoriasis and their role in the metabolic disease linked to the skin disorder (Nami Niccolò, Clinical and Experimental Allergology and Immunology, XXVII cycle, tutor: M. Fimiani)
- Whole genome methylation profiles and survival of melanoma patients (Giulia Parisi, Clinical and Experimental Allergology and Immunology, XXVII cycle, tutor: M. Maio)
- Mutational study of p53 in patients with multiple myeloma Relapsed/Refractory (Benedetta Lucani, Clinical and Experimental Allergology and Immunology, XXVII cycle, tutor: M. Bocchia)
- Proteomic approach to characterizing interstitial pulmonary diseases (Alfonso Carleo, Clinical and Experimental Allergology and Immunology, tutor: P. Rottoli)
- BMD follow up evalation in patients with Cerebrotendinous Xanthomatosis (Martina Ruvio, Osteo-Metabolic diseases, XXVII cycle, tutor: R. Nuti)
- Possible protective role of some Mediterranean diet foods in relation to gastric cancer (Daniela Barone, Oncological Genetics, XXVII cycle, tutor: A. Giordano)
6th June 2012 h 16.30 - 19.30 room 7
- P2X7 Receptor Protein in Multiple Sclerosis (Cinzia Montilli, Clinical Pharmacology, XXV cycle, tutor: F. Laghi Pasini)
- Purinergic receptors and cardiac remodeling (Stefania Zimbone, Clinical Pharmacology, XXVI cycle, tutor: F. Laghi Pasini)
- Life at the extreme limit: phenotypic characteristics of 100 centenarians admitted to geriatric institute 'Pio Albergo Trivulzio (Valentina Guercio, Hepatobiliopancreatic diseases and multitumoral syndromes, XXV cycle, tutor: F. Cetta)
- Analysis and immunoistochemistry of decorin in localized scleroderma before and after UVA-1 treatment (Pianigiani Anna Paola, Clinical and Experimental Allergology and Immunology, tutor: M. Fimiani)
- Recessive phenotypes in 22q11.2 region (Mucciolo Mafalda, Medical Genetics, XXIV cycle, tutor: F. Mari)
- Integrating role of T-antigen, Rb2/p130, CTCF and Boris in mediating non-canonical endoplasmic reticulum-dependent death pathways triggered by ER-chronic stress in mouse medulloblastoma (Valeria Rizzo, Oncological Genetics, XXVI cycle, tutor: A. Giordano) - Videoconference from Philadelphia
9th May 2012 h 16.30 - 19.30 room 7
- A new gene contiguous syndrome at 22q13, not involving SHANK3 gene (Maria Antonietta Mencarelli, Medical Genetics, XXVI cycle, tutor: A. Renieri) 10 min
- Small molecules mimicking the spa310 peptide from the spacer region of pRB2/p130 as potential
anticancer agents (Conti Daniele, Oncological Genetics, XXIV cycle, tutor: A. Giordano)
- Possible role of densitometry of the hand in the prognostic assessment and therapeutic monitoring of rheumatoid arthritis. Correlation with instrumental, clinical and biochemical indices (Bertoldi Ilaria, Experimental Rheumatology, XXV cycle, tutor: M. Galeazzi)
- Chemerin role in chronic inflammatory arthritis (Valcamonica Elisabetta, Experimental Rheumatology, XXV cycle, tutor: M. Galeazzi)
- LOX-1 genetic variants distribution, similarities and differences between the Caucasic population and sub saharian african population in primary and secondary prevention in relation to existing classic risk factors for atherothrombosis (Kimani Jane Lucie, Experimental Medicine and Atherosclerosis, XXV cycle, tutor: L. Puccetti)
- Outcome of surgical treatment of colorectal cancer in the elderly (Fontani Andrea, Colorectal and Gastroesophageal Disease, XXV cycle, tutor: S. Civitelli)
11th April 2012 h 16.30 - 19.30 room 7
-ERK8 involvement in autophagy (David Colecchia, Medical Genetics, XXIV cycle, tutor: M. Chiariello)
-Genetic screening and clinical therapeutical implications in Paget's disease of bone (Merlotti Daniela, Osteo-Metabolic diseases, XXV cycle, tutor: R. Nuti)
-Antitumor activity of new pyrazolo pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines (Cozzi Martina, Oncological Genetics, XXIV cycle, tutor: A. Giordano)
-Rett Networked Database: an integrated clinical and genetic network of Rett syndrome databases (Grillo Elisa, Medical Genetics, XXV cycle, tutor: F. Ariani)
-Bioinformatics approach for detecting and quantifying the amount of metastasis in cancer tissue (Olaynka Olabinjo, Oncological Genetics, XXV cycle, tutor: A. Giordano) - Videoconference from Philadelphia
7th March 2012 h 16.30 - 19.30 room 3
- New strategies for the cure of malignant mesothelioma by using p53 activating molecules (Iris Maria Forte, Oncological Genetics, XXIV cycle, tutor: A. Giordano)
- Identification of a novel p190-derived breakpoint peptide suitable for peptide vaccine therapeutic approach in Ph+ acute lymphoblastic leukemia patients (Defina Marzia, Clinical and Experimental Allergology and Immunology, XXV cycle, tutor: M. Bocchia)
- The involvement of inflammation and oxidative stress biomarkers into two different studies: evaluation in experimental models and in humans (Zangari Rosalia, Hepatobiliopancreatic diseases and Multitumoral syndromes, XXIV cycle, tutor: F. Cetta)
- The key role of interleukin 17 in psoriasis and other autoimmune diseases (Cervadoro Elisa, Clinical and Experimental Allergology and Immunology, XXV cycle, tutor: M. Fimiani)
1st February 2012 h 16.30 - 19.30 room 4
- Analysis of aberrant constitutional DNA methylation in patients with colorectal cancer and multiple primary tumors (20’ Crucianelli Francesca, Colorectal and gastroesophageal diseases, XXIV cycle, tutor: S. Civitelli, M. Genuardi)
- New technologies to study Rett syndrome (20’ Gabriella Livide, Medical Genetics, XXV cycle, tutor: F. Ariani, A. Renieri)
- Alteration of aortic constituents in thoracic aortic aneurysm and role of MMPs, TIMPs and GGT in the pathogenesis of the disease (20’ Cappelli Alessia, Experimental Medicine and Atherosclerosis, XXVI cycle, tutor: P. Tanganelli)
14th December 2011 h 16.30 - 19.30
- Analysis of phenotype risks/environmental factors and serum levels of 1,25-dihydroxy vitamin D3 in patients with “fast growing melanoma” (20’ Mandato Filomena, Clinical and experimental Allergology and Immunology, XXVI cycle, tutor: M. Fimiani)
- Prognostic significante of IGHV1-69 gene in Chronic Lynphocytic Leukemia (20’Sicuranza Anna, Clinical Pharmacology, XXVI cycle, tutor: M. Bocchia)
- Investigating new microdeletion syndromes (20’ Disciglio Vittoria, Medical Genetics, XXIV cycle, tutor: F. Mari, A. Renieri)
- Alport syndrome and Next Generation Sequencing (20’ Chiara Fallerini, Medical Genetics, XXVI cycle, tutor: A. Renieri)
Progress report Schedule, academic year 2015-2016
Date to be determined - Centro Didattico Le Scotte
- Cheleschi Sara (A. Fioravanti, M. Galeazzi)
Title: "Evaluation of a new pharmacological compound by an in vitro study on human osteoarthritic chondrocytes"
- De Palma Anna (A. Fioravanti, M. Galeazzi)
Title to be defined
- Barsotti Simone (M. Mosca)
Title to be defined
- Antonuzzo Lorenzo (A. Arcangeli)
Title: "Valutazione dell’espressione e del ruolo prognostico del canale del potassio human etere-a-go-go-related nelle neoplasie neuroendocrine del pancreas"
- Iorio Jessica (A. Arcangeli)
Title: "Functional relationships between k+ channels and pH- regulating mechaninsms in colorectal cancer"
- Montella Antonio (R. Nuti)
Title: "Three years evaluation of scleroderma patients in order to identify a disease progression index"
July 14, 2016 at 13:30 - Centro Didattico Le Scotte, Room 13
- Guarnieri Giulia (Vannelli)
Title: "Study of genetic and epigenetic mechanisms regulating neurogenesis in human cholinergic neurons"
- Menicacci Beatrice (M. Del Rosso)
Title: "Senescence secretory phenotype and tumor microenvironment: modulation by polyphenolic compounds"
- Sarti Samanta (L. Poliseno)
Title: "Assessing the biological role of miR-211 family in a zebrafish melanoma model"
- Lamberti Arianna (M. Fimiani)
Title: "Genetic and molecular aspects as possible predictive clinical evolution of Lymphomatoid Papulosis"
June 29, 2016 at 14:00 - Centro Didattico Le Scotte, Room A
- Imperatore Valentina (A. Renieri)
Title: "Massive parallel sequencing in sporadic retinoblastoma patients reveals somatic mosaicism"
- Landucci Elisa (A. Renieri)
Title: "Modeling Rett syndrome with iPSCs-derived neurons"
- Pinto Anna Maria (A. Renieri)
Title: "Molecular basis of Arteriovenous Malformations (AVMs)"
-Daga Sergio (A. Renieri)
Title: "In vitro podocyte-like cell system: a new approach to understand Alport Syndrome"
June 23, 2016 at 13:30 - Centro Didattico Le Scotte, Room 6
- Grassi Susanna (S. Galimberti)
Title: "Pharmacogenomic, epigenetic, proteomic, and immunological variables as possible predictive markers of response and toxicity in patients affected by chronic myeloid leukemia (CML) receiving tyrosin kinase inhibitors (TKIs)"
- Penon Antonella (A. Giordano)
Title: "Study of the role of various tomato cultivars in colorectal cancer development"
- Bennett David (P. Rottoli)
Title: "Research of clinical biomarkers with diagnostic and prognostic meaning in patients with interstitial lung diseases and lung transplant"
- Astarita Carlo (A. Giordano)
Title: "Hormone imbalance promotes eye disease through chronic cellular stress"
Maggio 12, 2016 at 13:00 - Centro Didattico Le Scotte, Room 14
- Montini Marco (S. Conticello)
Title: "Assaying the order of events in cells through CRISPR/Cas9"
- Tommolini Federica (E. Carnevali)
Title: "New frontiers in genetic investigation for forensic purposes: implementation of SNPs analysis system for predicting phenotypic traits (eye color) from a biological stain"
March 30, 2016 at 14:00 - Centro Didattico Le Scotte, Room 14
- Lopomo Angela (L. Migliore)
Title: "Genetic and epigenetic biomarkers in myasthenia gravis"
- Stoccoro Andrea (L. Migliore)
Title: "Epigenetic mechanisms in Mitochondrial Diseases"
- Mori Elena (P. Dello Sbarba)
Title: "Serum metabolomic profiles for discriminating early from metastatic disease and predicting relapse in patients with colorectal cancer"
- Poteti Martina (P. Dello Sbarba)
Title: "The metabolic profile of Chronic Myeloid Leukaemia stem cell subsets as a target to suppress minimal residual disease resistant to tyrosine kinase inhibitors"
- Tubita Alessandro (P. Dello Sbarba)
Title: "Targeting the Mitogen-Activated Protein Kinase ERK5 in human melanoma"
- Vitale Stefania (P. Dello Sbarba)
Title: "Role of endocrine therapy in combination with anti-HER2 therapy and CDK4/6 inhibitors in hormone receptor positive/HER2 positive breast cancer"
March 4, 2016 at 14:00 - Centro Didattico Le Scotte, Room 13
-Chiarucci Carla (M. Maio)
Title: "Identification of immune-related biomarkers that can be predictive for clinical responses to targeted
therapies in melanoma patients"
- Fazio Carolina (M. Maio)
Title: "Pre-clinical development of new combined epigenetic and immunotherapeutic approaches for (the treatment of ) malignant mesothelioma"
- Giacobini Gianluca (M. Maio)
Title: "Identification of immune correlates of clinical activity and/or disease outcome in melanoma patients
undergoing immunotherapy or targeted therapy"
- Lofiego Maria (M. Maio)
Title: "A new human cell-based vaccine for cancer therapy: pre-clinical characterization"
February 19, 2016 at 14:00 - Centro Didattico Le Scotte, Room 13
- Belcastro Eugenia (A. Pompella)
Title: "Inflammation and denitrosating enzymes: from the development of a cellular inflammatory model to pathological tissues"
- Delaram Rahmani (A. Giordano)
Title: "Characterization of the CISD2 mutation of Wolfram syndrome 2 in fibroblasts and iPSC derived cells"
February 10, 2016 at 14:00 - Centro Didattico Le Scotte, Room 6
-Caporaso Antonella (A. Giordano)
Title: "Characterization of p54/NONO molecular degradation mechanism"
- Iannuzzi Carmelina (A. Giordano)
Title: "Tackling malignant mesothelioma : multiple approaches are required"
January 29, 2016 at 14:00 - Centro Didattico Le Scotte, Room 6
- Mancuso Pietro (A. Giordano – A. Bellacosa)
Title: "Role of TDG in DNA demethylation and transcriptional regulation in melanoma"
January 22, 2016 at 14:00 - Centro Didattico Le Scotte, Room 6
- Aprile Lara (M. Bocchia)
Title: "Increased atherothrombotic risk and nilotinib treatment in chronic myeloid leukemia patients: a probable role for genetic predisposition and induced pro-inflammatory/pro-oxidative status"
- Cencini Emanuele (M. Bocchia)
Title: "Study of gene polymorphisms as predictors of treatment efficacy and toxicity in patients with non-Hodgkin lymphomas"
- Papini Giulia (M. Bocchia)
Title: "Prognostic role of the quantification of NPM1 minimal residual disease in NPM1 positive AML patients"
- Fanelli Tiziana (A. Vannucchi)
Title: "Clonal heterogeneity and clonal progression in the leukemic transformation of chronic myeloproliferative neoplasms"
- Corbizi fattori Giuditta (A. Vannucchi)
Title: "Exploiting mutated calreticulin for diagnostic, prognostic and therapeutic purposes in chronic myeloproliferative neoplasms"
Progress report schedule, academic year 2019-2020
January 24th, 2020 at 1pm, Centro Didattico Le Scotte, room 14
- Salvadori Costanza (tutor Prof. Paola Guglielmelli)
Title: "Study of the role of circular-RNA in patients with MPN"
- Pacelli Paola (tutor Prof. Monica Bocchia)
Title: "Evaluation of Multiple Myeloma (MM) Minimal Residual Disease by using Next Generation Flow in patients undergoing Doratumumab therapy"
- Bacchiarri Francesca (tutor Prof. Monica Bocchia)
Title: "Comprehensive evaluation by flow analysis of circulating plasma cells in smoldering multiple myeloma patients"
- Mazziotta Francesco (tutor Dr. Sara Galimberti)
Title: "Treatment Resistance and Immune Escape in Acute Leukemia"
February 6th, 2020 at 1pm, Centro Didattico Le Scotte, room 14
- Ferrigno Ilaria (tutor Prof. Monica Bocchia)
Title: "Prognostic role of isocitrate dehydrogenases 1 and 2 mutations (IDH1/IDH2) in Acute Myeloid Leukemia"
- Sant'Antonio Emanuela (tutor Prof. Alessandro Maria Vannucchi)
Title: "Understanding the genetic and epigenetic basis of JAK-inhibitors resistance"
- Ciofini Sara (tutor Prof. Monica Bocchia)
Title: "New prognostic markers in acute myeloid leukemia: focus on PD1-PDL1, Bcl2 and mitochondrial mass"
- Mannelli Lara (tutor Prof. Alessandro Maria Vannucchi)
Title: "The role of RUNX1 in chronic and blast phase myeloproliferative neoplasms"
February 20th, 2020 at 1pm, Centro Didattico Le Scotte, room 14
- Cameli Paolo (tutor Prof. Elena Bargagli)
Title: "Therapy of IPF: "real-life" experience with pirfenidone in the ILD Referral Centre of Siena"
- D'Alessandro Miriana (tutor Prof. Elena Bargagli)
Title: "Bronchoalveolar lavage biomarkers in idiopathic pulmonary fibrosis"
- Bergantini Laura (tutor Prof. Elena Bargagli)
Title: "Analysis of biomarkers in Bronchoalveolar lavage fluid in Patients with sarcoidosis"
- Fui Annalisa (tutor Prof. Elena Bargagli)
Title: "Alfa1 antitrypsin deficiency in interstitial lung diseases"
- Fortunato Diogo (tutor Prof. Elisa Frullanti)
Title: "Development of extracellular vesicle-targeting tools for novel liquid biopsy approaches in lung cancer"
March 5th, 2020 at 1pm, online
- Anichini Giulia (tutor Dr. Barbara Stecca)
Title: "Role of the Hedgehog pathway in cholangiocarcinoma"
- Simeone Irene (tutor Prof. Andrea Galli)
Title: "Metabolic reprogramming of hepatocellular carcinoma by oncogenic RuvBL1"
- Beltrami Matteo (tutor Prof. Ranuccio Nuti)
Title: "Hypertrophic cardiomyopathy: Correlation with genetic and pathological substrates, functional capacity and prognostic stratification"
- Zuanelli Brambilla Corrado (tutor Prof. Monica Bocchia)
Title: "AML/MDS relapse after allogeneic stem cell transplantation"
March 20th, 2020 at 1pm, online
- De Paolo Raffaella (tutor Prof. Laura Poliseno)
Title: "Zebrafish model in melanoma research: analysis of coding and non-coding BRAF variants"
- D'Angelo Costantino (tutor Prof. Antonio Giordano)
Title: "Evaluation of anti-proliferative and antioxidant potential of tomatoes extracts against melanoma"
- Baldanzi Caterina (tutor Dr. Laura Poliseno)
Title: "Identification of the molecular mechanisms by which pigmentation limits vemurafenib activity in melanoma cells"
- Lucchese Anna Maria (tutor Prof. Antonio Giordano)
Title: "Role of Pygo2 and canonical Wnt/b-Catenin signaling on mediating melanoma in the Zebrafish animal model"
- Lombardi Zoe (tutor Prof. Elisabetta Rovida)
Title: "Optimization of extracellular signal-regulated kinase 5 (ERK5) targeting in melanoma"
April 2nd, 2020 at 1pm, online
- Costa Aurora (tutor Prof. Antonio Giordano)
Title: "Pharmacological reactivation of RBL2/p130 could be an effective antitumoral strategy for malignant pleural mesothelioma"
- Bottaro Maria (tutor Prof. Antonio Giordano)
Title: "Targeting mitochondrial folate metabolism for mesothelioma treatment"
- Fulco Beniamino (tutor Prof. Antonio Giordano)
Title: "Preventive and antiproliferative effects of tomato extracts on colorectal cancer"
April 16th, 2020 at 1pm, online
- Trusso Maria Allegra (tutor Prof. Andrea Fagiolini)
Title: Exome sequencing of a family identifies some potential candidate genes contributing risk to bipolar disorder
- Dell'Aquila Milena (tutor Prof. Antonio Giordano)
Title: Phosphoproteomic screening reveals the multiple functions of cdk9 in DNA damage response
- Farhad Jahanfar (tutor Prof. Annarosa Arcangeli)
Title: High throughput screening of ion channel blockers
- Nicolì Vanessa (tutor Prof. Lucia Migliore)
Title: A study on epigenetic modifications in human placentas and buccal mucosa cells of mothers and newborns
- Gallo Roberta (tutor Prof. Lucia Migliore)
Title: Association between maternal pregnancy factors and gene-specific methylation in girls with Autism Spectrum Disorders
April 30th, 2020 at 1pm, online
- Lembo Gaia (tutor Dr. Silvestro Conticello)
Title: Drugging the mutators: Design of inhibitors of APOBECs
- Torrini Serena (tutor Dr. Silvestro Conticello)
Title: Assessing the fate of APOBEC1-edited transcripts through NGS technologies
- Barone Federica (tutor Dr. Rosario Notaro)
Title: Investigation of complement inhibition for the treatment of Paroxysmal Nocturnal Hemoglobinuria
- Bindi Ilaria (tutor Prof. Marco Mandalà)
Title: Audiological features in Alport syndrome: preliminary results
- Campoli Marco (tutor Prof. Pietro Rubegni)
Title: Proactive sinecatechins for the treatment of cutaneous HPV-related lesions
May 14th, 2020 at 1pm, online
- Carriero Miriam (tutor Prof. Francesca Mari)
Title: CRISPR/Cas9-based targeted genome editing for the correction of CDKL5 deficiency disorder in patient-derived cells
- Capitani Katia (tutor Dr. Silvestro Conticello/Prof. Alessandra Renieri)
Title: Gene editing of clinically-relevant mutations in IQSEC2-related intellectual disability, Rett syndrome, Parkinson disease, Alport syndrome and Pompe disease
- Lorenzetti Flaminia Clelia (tutor Prof. Alessandra Renieri)
Title: Personalized therapy for TP53 mutated CLL patients based on CRISPR-Cpf1 and suicide gene delivery
- Croci Susanna (tutor Prof. Ilaria Meloni)
Title: High efficiency of HDR-CRISPR/Cas9 gene editing of MECP2 and FOXG1 mutations in mitotic and post-mitotic cells
- Alaverdian Diana (tutor Prof. Elisa Frullanti)
Title: Gene editing in Epilepsy and mental retardation limited to females (EFMR)
- Beligni Giada (tutor Prof. Francesca Ariani)
Title: Correction of Gly2019Ser variant in LRRK2 gene through CRISPR/Cas9 approach in Parkinson Disease
May 28th, 2020 at 1pm, online
- Di Sarno Laura (tutor Prof. Stefano Giannotti)
Title: An overview of MSCs application in tendon and bone regeneration
- Romitelli Antonia (tutor Dr. Silvestro Conticello)
Title: Assaying the order of transcriptional events in cells by CRISPR/Cas9
- Bruno Lucia Pia (tutor Prof. Elisa Frullanti)
Title: Exploring genetic bases of intellectual disability through exome sequencing analysis
- Palmieri Maria (tutor Prof. Elisa Frullanti)
Title: CfDNA-NGS Liquid Biopsy for solid cancer and vascular malformations
June 11th, 2020 at 1pm, online
- Maiorano Patrizia (tutor Prof. Antonio Giordano)
Title: Virtual reality and music therapy as distraction interventions to alleviate anxiety and improve mood states in breast cancer patients during chemotherapy
- Moccia Annalisa (tutor Dr. Maria De Angioletti )
Title: Role of ETS proteins in determining specific oncogenic phenotypes in prostate cancer
- Tarantino Danilo (tutor Dr. Silvestro Conticello)
Title: The weight of APOBEC mutations in cancer development
- Franci Lorenzo (tutor Dr. Mario Chiariello)
Title: A new role for MAPK15 in metabolism
- Dapporto Francesca (tutor Dr. Mario Chiariello)
Title: Brain microsurgery for the administration of drugs in glioblastoma
July 3rd, 2020 at 1pm, online
- Bruno Martina (tutor Prof. Antonio Giordano)
Title: RBL2/p130 reactivation strategy and possible mechanisms that could involve RBL2/p130 in the EMT in prostate cancer
- Dragoni Gabriele (tutor Dr. Andrea Galli)
Title: The role of citrullination in Crohn's disease: the effect of PAD enzymes in intestinal inflammation and fibrosis
- Bouazzi Rayhana (tutor Prof. Annarosa Arcangeli)
Title: Targeting ion channels and adhesion receptor interaction during PDAC progression by pH-sensitive engineered antibodies
- Livraghi Luca (tutor Dr. Angelo Di Leo)
Title: Tracking somatic mutations in BRCA1 and BRCA2-associated breast cancers through circulating tumor DNA
- Palomino Villcas Juan De Dios (tutor Dr. Silvestro Conticello)
Title: Identifying factors involved in extrachromosomal circular DNA biogenesis and clearance
- Cannito Sara (tutor Prof. Miche Maio)
Title: Modeling of cancer immune phenotype by new epigenetic drugs: a strategy to improve efficacy of immunotherapy
July 9th, 2020 at 1pm, online
- Romagnoli Simone (tutor Prof. Alessandro Maria Vannucchi)
Title: Bioinformatics: linking Genetics, Oncology and Clinical Medicine
- Romagnoli Dario (tutor Dr. Angelo Di Leo)
Title: Identification and development of epigenetic tumor biomarkers through computational biology approaches
- Pettini Francesco (tutor Prof. Simone Furini)
Title: Molecular Dynamics Simulation of Protein-Peptide recognition
- Frassineti Lorenzo (tutor Dr. Angelo Di Leo)
Title: Development of a multimodal system for monitoring of brain disorders in children: Neonatal Seizure Detection
- Benetti Elisa (tutor Prof. Simone Furini)
Title: MLI-score: a machine learning tool generating an integrated score for pathogenic variant prediction
- Martignano Filippo (tutor Dr. Silvestro Conticello)
Title: Nanopore sequencing and liquid biopsy
July 16th, 2020 at 1pm, online
- Vitale Antonio (tutor Prof. Luca Cantarini)
Title: Role of Colchicine Treatment in Tumor Necrosis Factor Receptor Associated Periodic Syndrome (TRAPS): Real-Life Data From the AIDA Network
- Giani Teresa (tutor Prof. Rolando Cimaz)
Title: Juvenile idiopathic arthritis: the expanding role of Th17 cells in cartilage damage
- Elefante Elena (tutor Prof. Marta Mosca)
Title: Integrating patient reported outcomes, clinical data and quality indicators to physician driven data in clinical management of chronic rheumatic diseases: the paradigm of Systemic Lupus Erythematosus (SLE)
- D'Ignazio Alessia (tutor Prof. Franco Roviello)
Title: Preoperative oral immunonutrition in gastrointestinal surgical patients: how the tumor’s microenviroment can be modified
- Daffinà Maria Grazia (tutor Prof. Michele Maio)
Title: The role of soluble PD-L1 as a predictive biomarker in mesothelioma patients treated with immune-checkpoints inhibitors
- Gambale Elisabetta (tutor Prof. Michele Maio)
Title: Epigenetic immunomodelling to improve the efficacy of immunotherapy and to overcome resistance to immunotherapy in melanoma: the NIBIT-ML1 study NCT04250246
- Damato Angela (tutor Prof. Antonio Giordano)
Title: Genetic and clinical analysis in patients with advanced colorectal cancer enrolled in the Phase II NIVACOR trial
- Pepe Sara (tutor Dr. Barbara Stecca)
Title: CD47 as a novel immunotherapy target of Hedgehog pathway