https://sites.google.com/dbm.unisi.it/gen-covid

Coordinator: Alessandra Renieri

Source: HEDIMED

Title: Human exposomic determinants of immune mediated diseases

Date and cost of project: COST for our UNIT 75,000EUR

PI: Elena Bargagli

Source: MIUR, EU joint programme - Neurodegenerative Disease Research

Title: Humanized high-throughput co-culture system for motor neuron diseases

Date and cost of project: 2020, 1.079,915EUR (149,450EUR to Silvo Conticello Unit)

PI: Eran Perlson (Tel Aviv University)

Source: AtomWise Academic Awards

Title: Identification of APOBEC inhibitors

Date and cost of project: 2020, 5,000EUR

PI: Silvo Conticello

Source: Telethon

Title: Costruzione di una biobanca per lo studio delle malattie genetiche

Date and cost of project: 30,000EUR

PI Alessandra Renieri

Source: Istituto Toscano Tumori (ITT)

Title: Identification of genetic bases of individual predisposition to lung cancer in non-smokers

Date and cost of project: 118,000EUR

PI Alessandra Renieri

Source: Associazione Italiana Ricerca Cancro (AIRC)

Title: Metabolic characterization and targeting of Chronic Myeloid Leukaemia stem cells resistant to tyrosine kinase inhibitors

Date and cost of project: 280,000EUR

PI Alessandra Renieri

Source: Comunità europea (H2020)

Title: Diagnosis and Management Of febrile illness using RNA Personalised Medicine Signature Diagnosis

Date and cost of project: 2020-2025, 400,000EUR

PI Rolando Cimaz

Source: HORIZON 2020 Comunità Economica Europea

Title: Studio dei marcatori di asma branchiale nell’adulto con approccio combinato (studio esosomi e proteomica degli esosomi)

Date and cost of project: 2020-2025

PI Elena Bargagli

Source: Regione Toscana

Title: Development of personalized diagnosis and innovative therapies for resistant CLL Development of personalized diagnosis and innovative therapies for resistant CLL

Date and cost of project: 2020-2023 euro 790,000EUR

PI: Maria De Angioletti

Capo fila progetto: Cosima Baldari

Source: Associazione Italiana per la Ricerca sul Cancro (AIRC)

Title:Metabolic characterization and targeting of Chronic Myeloid Leukaemia stem cells resistant to tyrosine kinase inhibitors

Date and cost of project: 2020-2024, 415,000EUR/5years

PI: Persio Dello Sbarba

Source: Regione Toscana- Programma per la Ricerca in Materia di Salute 2018

Title: The achievable cure in Chronic Myeloid Leukemia: unravelling CD26+ leukemia stem cell features to enable safe tyrosine kinase inhibitor discontinuation - stemCMLcure

Date and cost of project: 2020-2022, 80,000EUR

Responsabile scientifico generale del progetto: prof. Monica Bocchia

PI Persio Dello Sbarba

Source: Associazione Italiana per la Ricerca sul Cancro (AIRC), IG grant

Title: Role of Hedgehog signaling in melanoma immune response

Data and cost of project: 2020-2024, 430,100EUR

PI: Barbara Stecca

Source: Bando Salute 2018

Title: Pre-clinical development and characterization of GLI-selective therapeutics for treatment of basal cell carcinoma and melanoma

Data and cost of project: 2020-2022, 400,000EUR

PI: Barbara Stecca

Source: Breast Cancer Research Foundation (BCRF), New York - USA

Title: The TOUCH trial - To reduce the use of chemotherapy in patients with ER positive and HER2 positive breast cancer

Date and cost of project: 01/10/2019-30/09/2020, 250,000USD

PI: Angelo Di Leo

Source: Associazione Italiana per la Ricerca sul Cancro (AIRC)

Title: Dissecting the role of extracellular signal-regulated kinase 5 in cellular senescence and drug resistance in melanoma

Date and cost of project: 2019-2024, 446,000 Euro

PI: Elisabetta Rovida

Source: Ente cassa risparmio Firenze

Title: Sequenziamento a nanopori di terza generazione – Oxford Nanopore per la Diagnosi Prenatale

Date and cost of project: 2019‐2020, 20,000EUR

PI: Alessandro Maria Vannucchi, Bartalucci

Source: Regione Toscana

Title: Proton pump inhibitoRs in an elderly pOpulation and increaseD torsadES de pointTes risk (PRODEST)”

Date and cost of project: 2019-2021, 155,000EUR

PI: Pier Leopoldo Capecchi

Source: Ministero della Salute-Finalizzata

Title: CALR: Exploiting Calreticulin mutations a model for personalized medicine in MPN

Date and cost of project: 2019‐2022, 494,700EUR

PI: Alessandro Maria Vaannucchi

Source: Ministero della salute-Finalizzata

Title: MASTO: Strategie di medicina personalizzata nella mastocitosi sistemica

Date and cost of project: 2019‐2022, 330,000EUR

PI: Alessandro Maria Vannucchi, Paola Guglielmelli, Pieri

Source: Ministero della salute-PRIN 2017

Title: Myeloid Neoplasms: an integrated clinical, molecular and therapeutic approach

Date and cost of project: 29/08/2019‐29/08/2022 221,953EUR

PI: Alessandro Maria Vannucchi

Source: Heidelberg university

Title: e‐MPN: European Myeloproliferative Neoplasm Network

Date and cost of project: 2019‐2023, 100,000EUR

PI: Subcontractor- Alessandro Maria Vannucchi

Source: SevenBridges Genomics

Title: Analysis of Retroelement insertions in cancer genomes

Date and cost of project: 7/2019, €10000

PI: Silvo Conticello

Source: Regione Toscana Bando Ricerca Salute 2018

Title: The achievable cure in Chronic Myeloid Leukemia: unravelling CD26+ leukemia stem cell features to enable safe tyrosine kinase inhibitor discontinuation (stemCMLcure)

Date and cost of project: 2018-2021, 280,000EUR

PI Alessandra Renieri

Source: Associazione italiana per la ricerca sul cancro (AIRC )

Title: MYNERVA: Actionable targets in clonal progression and systemic spreading of myeloid neoplasms

Date and cost of project: 01/07/2018‐30/06/2025 2.100,000EUR

PI: Alessandro Maria Vannucchi

Source: Associazione italiana per la ricerca sul cancro (AIRC )

Title: ACCELERATOR: Early detection and intervention: Understanding the mechanisms of transformation and resistance of incurable haematological malignancies

Date and cost of project: 01/12/2018‐30/11/2023 70,000EUR/year

PI: Alessandro Maria Vannucchi

Source: ITT GRANT 2013

Title: Mutations of calreticulin in Philadelphia‐chromosome negative chronic myeloproliferative neoplasms:understanding mechanisms and clinical correlates”

Date and cost of project: 2017‐2020 192,000EUR

PI: Alessandro Maria Vannucchi

Source:Miur PRIN 2017-2020

Title: Flogosi sistemica e rischio aritmico: ruolo della Interleuchina-6 nel rimodellamento elettrico atriale reversibile attraverso variazioni nella espressione delle Connessine

Date and cost of project: 2017-2020, 100,182EUR

PI: Pier Leopoldo Capecchi

Source: Italian Ministry of Health

Title: The oncogenic potential of the AID/APOBECs: involvement in tissue transformation and oncogenesis - new tools to better model cancer

Date and cost of project: 7/2016, €382,008

PI: Silvo Conticello

Renieri A, Conticello S, Pinto AM, Meloni I, Daga S, Donati F, Croci S, Lopergolo D. “CRISPR-Cas system for gene therapy” (Patent application N° 102018000020230) for the use of CRISPR/Cas9 technology in rare genetic diseases. December 19, 2018.

Renieri A, Conticello S, Donati F, Niccheri F, Mari F, Papa FT, Lorenzetti FC. “Sistema CRISPR-Cas per l’editing genomico” (Patent application N° 102018000009431) for the employment of CRISPR/Cpf1 technology for specific delivery of suicide gene in cancer cells mutated in TP53. October 15, 2018.

Antonio Giordano, “Peptide inhibitors of cyclin-dependent kinase activity and uses thereof” U.S. Patent No. 7,470,670

Antonio Giordano “Human cyclin-dependent kinase-like proteins and methods of using the same.” U.S. Patent No. 6,822,080 Issued: 11/23/2004

Alessandra Renieri e Ilaria Meloni "Diagnostic and therapeutic tools for X-linked mental retardation syndrome " International application No PCT/IT03/00134) issued March 2003 (se also research activity on Mental Retardation)

Antonio Giordano “A Method of Inhibiting Cancer Cell Growth Using a Vector Expressing pRb2/P130.” U.S. Patent No. 6,663,856 Issued: 12/16/2003

Antonio Giordano “Methods of Inhibiting Smooth Muscle Cell Proliferation and Preventing Restenosis with a Vector Expressing Rb2/P130.” U.S. Patent No. 6,596,698 Issued: 07/22/2003

Antonio Giordano "pRb2/p130 Peptide Inhibitors of cdk2 Kinase activity" U.S. Patent No. 6,297,357 issued on October 2 2001.

Antonio Giordano "Determination of Cyclin-Dependent Kinase Inhibitor p27 levels as a prognostic factor in cancer patients." U.S. Patent No. 6,180,333 issued on January 30, 2001.

Antonio Giordano, “Human Cyclin-Dependent Kinase-like Proteins and Methods of Using the Same,” U.S. Patent No. 6,162,612, issued on December 19, 2000.

Antonio Giordano and A. Baldi, “Human Retinoblastoma-Related (pRb2/p130) Genomic DNA and Methods of Detecting Mutations Therein. US. Patent Patent No. 5,807,681, issued on Sep. 15, 1998.

Antonio Giordano, “Human Cyclin-Dependent Kinase-like Proteins and Methods of Using the Same,” U.S. Patent No. 5,674,748, issued on October 7, 1997.

Antonio Giordano, ”Tumor Suppressor Protein pRB2, related gene products, and DNA encoding therefor” U.S. Patent No. 5,532,340, issued July 2, 1996.

Antonio Giordano, ”Tumor Suppressor Protein pRB2, related gene products, and DNA encoding therefor” U.S. Patent No. 5,457,049, issued October 10, 1995.

Source: Ministero della Salute

Title: “Identification of common biological pathways in Rett patients mutated in MECP2, CDKL5 and FOXG1”

Date and cost of entire project: 2012-2016 Euro 248.440,00

PI: Alessandra Renieri

Source: Telethon

Title: “Cell lines and DNA bank of Rett syndrome, X-linked mental retardation and other genetic diseases”

inside the general project: "Telethon Network of Genetic Biobanks"

Date and cost of entire project: 2013-2017 Euro 37.000,00 per year

PI: Alessandra Renieri

Source: Associazione Italiana per la ricerca sul Cancro

Title: "Melanoma cell therapy: endothelial progenitor cells as shuttles of anticancer agents"

Date and cost of entire project: 2013-2016 Euro 255.000

PI: Mario Del Rosso

Source: Italian Cystic Fibrosis Research Foundation

Title: "GSH inhalation therapies in CF : how useful, how safe? Set-up of a CF murine model for monitoring of inflammation in vivo and assessment of convenient alternatives"

Date and cost of entire project: 2014-2016 Euro 56000

PI: Alessandro Corti

Source: Ministero della Salute

Title: "The oncogenic potential of the AID/APOBECs: involvement in tissue transformation and oncogenesis - new tools to better model cancer"

Date and cost of entire project: 2014-2017 Euro 341.387,16 (Euro 183.228,14 for the PI)

PI: Laura Poliseno

Source: Provincia Autonoma di Trento

Title: "Studio clinico e genetico di pazienti con malformazioni vascolari ad eredità mendeliane - 2. Clonaggio e studio funzionale di nuove mutazioni di FOXC2 - 3. dentificazione di nuovi geni-malattia attraverso l'intero esoma di famiglie con malformazioni vascolari ad eredità mendeliane - 4. Studio di mutazioni somatiche in campioni bioptici di malformazioni vascolari ad eredità mendeliane"

Date and cost of entire project: 2015-2016 Euro 700.000

PI: Matteo Bertelli

Source: University of Pisa

Title: "Nuovi fattori patogenetici e marker diagnostici di progressione dell’Artrite reumatoide"

Date and cost of entire project: 2015-2016 Euro 35.000

PI: Alfonso Pompella

Source: Istituto Toscano Tumorit

Title: "Peripheral arterial occlusive disease in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: role for a drug induced pro-atherothrombotic status"

Date and cost of entire project: 2015-2017 Euro 93.000

PI: Monica Bocchia

Source: Associazione Italiana per la Riceca sul Cancro

Title: "Prospective study of tyrosine kinase inhibitors induced pro-atherothrombotic status in chronic myeloid leukemia patients"

Date and cost of entire project: 2015-2017 Euro 153.000

PI: Monica Bocchia

Source: Istituto Toscano Tumori

Title: "Role of ERK5 in the selection of Chronic Myeloid Leukaemia cells in hypoxia in the design of strategies to suppress Minimal Residual Disease"

Date and cost of entire project: 2015-2018 Euro 209.000

PI: Persio Dello Sbarba

Source: Istituto Toscano Tumori

Title: "Acidity in tumor environment: Molecular bases to interfere with malignant progression and cancer stem cells"

Date and cost of entire project: 2015-2018 Euro 172.000

PI: Lido Calorini

Source: Novartis

Title: "preclinical study for optimizing cml stem cells detection by flow-cytometry"

Date and cost of entire project: 2016 Euro 22.000

PI: Monica Bocchia

Source: ECRF

Title: "Valutazione preclinica di nuovi antagonisti RGD e di inibitori delle metalloproteasi ad attività gelatinasica mediante analisi microPET/SPECT/CT"

Date and cost of entire project: 2016-2017 Euro 25.000

PI: Lido Calorini

Source: Regione Toscana, Bando Istituto Toscano Tumori

Title: "Mutations of calreticulin in myeloproliferative neopalsms: understanding mechanisms and clinical correlated"

Date and cost of entire project: 2016-2019 Euro 190.000

PI: Alessandro Maria Vannucchi

Source: Associazione Italiana per la ricerca sul Cancro, 5 per Mille

Title: "An integrated platform for clinical and molecular studies in myeloproliferative neoplasms"

Date and cost of entire project: 2016-2017 Euro 1.000.000

PI: Alessandro Maria Vannucchi

Source: Associazione Italiana per la ricerca sul Cancro

Title: "APOBEC1 in cancer development: a dual path to cancer"

Date and cost of entire project: 2016-2018 Euro 320.000

PI: Silvestro Conticello

Source: Associazione Italiana per la ricerca sul Cancro

Title: "miR-204 inhibition and attenuated Listeria monocytogenes: development of a novel therapeutic strategy against melanoma"

Date and cost of entire project: 2016-2018 Euro 221.000

PI: Laura Poliseno

Source: Ministero della Salute

Title: "The oncogenic potential of the AID/APOBECs: involvement in tissue transformation and oncogenesis - new tools to better model cancer"

Date and cost of entire project: 2016-2019 Euro 382.008 (Euro 305.619 for the PI)

PI: Silvestro Conticello

Source: Milheim Foundation For Cancer Research

Title: "The Adenovirus E1A Transforming region associate in vitro with two novel cellular factors"

Date and cost of entire project: 1993-1994 $ 15,000

PI: Antonio Giordano

Source: W. W. Smith Charitable Trust

Title: "Characterization and Identification of Novel Tumor Suppressor Genes"

Date and cost of entire project: 1993-1995 $ 184,000

PI: Antonio Giordano

Source: Telethon

Title: "Molecular Genetics of Alport syndrome"

Date and cost of entire project: 1994-1996 Lire 85.000.000

PI: Alessandra Renieri

Source: NIH RO1

Title: "p130/Rb2 a Novel Target for the Ad5 E1A Oncoproteins"

Date and cost of entire project: 19941997 $ 447,000

PI: Antonio Giordano

Source: The Council for Tobacco Research

Title: "The Role of pRb2 in Cell Proliferation"

Date and cost of entire project: 1995-1998 $ 150,000

PI: Antonio Giordano

Source: Sbarro Institute for Cancer research and Molecular Medicine

Title: "Cancer and Cell Cycle"

Date and cost of entire project: 1995-1999 $ 600,000

PI: Antonio Giordano

Source: Istituto Farmacoterapico Italiano (IFI)

Title: "Molecular cloning of the Tumor Liberated Protein (TLP)"

Date and cost of entire project: 1996-1997 $ 64,000

PI: Antonio Giordano

Source: Telethon

Title: "Cloning and characterization of the genes responsible for a new X-linked contiguous gene syndrome including Alport phenotype, mental retardation and elliptocytosis"

Date and cost of entire project: 1996-1998 Lire 148.000.000

PI: Alessandra Renieri

Source: The Council for Tobacco Research

Title: "The Role of pRb2 in Cell Proliferation"

Date and cost of entire project: 1998-1999 $ 35,000

PI: Antonio Giordano

Source: Associazione Emma ed Ernesto Rulfo per la Genetica Medica

Title: "Progressi verso la identificazione della base genetica della sindrome di Rett"

Date and cost of entire project: 1999-2001 Lire 30.000.000; anno 2003 Euro 13.000.

PI: Alessandra Renieri

Source: MURST cofin

Title: "Corrispondenza tra genotipo e fenotipo nell'eredità del glaucoma primario ad angolo aperto".

Date and cost of entire project: 1999-2001 Lire 154.000.000

PI: Alessandra Renieri

Source: Telethon

Title: "Molecular basis of AMME contiguous gene syndrome (A=Alport phenotype, M=mental retardation, M=midface hypoplasia and E=elliptocytosis) and single gene / phenotype correlation"

Date and cost of entire project: 2000-2003 Lire 306.000.000

PI: Alessandra Renieri

Source: PAR Università di Siena

Title: "Uso delle sequenze della Celera Genomics nell'era post-genomica e esempio di applicazione alle malattie neuropsichiatriche: Autismo e Complesso della Sindrome di Rett"

Date and cost of entire project: 2001 Lire 35.000.000

PI: Alessandra Renieri

Source: SOI

Premio ricerca scientifica SOI 2002

Date and cost of entire project: 2002 Euro 20.000,00

PI: Alessandra Renieri

Source: National Cancer Institute NIH R21 CA94802-01

Title: "Functional Interaction between HIV-1 products and cell cycle proteins"

Date and cost of entire project: 2002-2004 $ 100,000 20% effort

PI: Antonio Giordano

Source: PAR Università di Siena

Title: "Ruolo dei geni FACL4 e LAMA2 nella patogenesi della Sindrome di Rett e di disordini correlati"

Date and cost of entire project: 2002 Euro 24.000,00

PI: Alessandra Renieri

Source: NIH RO1 CA094804-02

Title: "Human Neurotropic JC Virus and CNS Diseases"

Date and cost of entire project: 2002-2006 $ 222,500

P.I.: K. Khalili Co P.I.: A. Giordano, 10% effort

Source: PA Dept of Health

Title: “Cancer Biomolecular Markers Research “

Date and cost of entire project: 2007- 2009 $ 2,000,000

PI: Antonio Giordano

Source: Ministero della Salute

Title: “Genomic structural variation studies in mentally retarded and normal individuals in Italy”.

Date and cost of entire project: 2008- 2010 Euro 90.200,00

PI: Alessandra Renieri

Source: PA Dept of Labor & Industry:

Title: “Workforce Development Grant”

Date and cost of entire project: 2009 $ 200,000

PI: Antonio Giordano

Source: Commonwealth of PA

Title: “Redevelopment Assistance Capital Project”

Date and cost of entire project: 2009 $ 1,500,000

PI: Antonio Giordano

Source: Department of Defense

Title: “Cancer Biomolecular Markers Research”

Date and cost of entire project: 2009-2010 $ 1,000,000

PI: Antonio Giordano

Source: A.I.R. (Associazione Italiana Rett)

Title: “Produzione di cellule neuronali da fibroblasti riprogrammati di pazienti con Sindrome di Rett: una tecnologia innovative per testare strategie terapeutiche”.

Date and cost of entire project: 2009-2010 Euro 50.000,00

PI: Alessandra Renieri

Source: PA Dept of Health

Title: “Identification of Cancer Stem Cells – a Powerful Weapon to Fight Cancer”

Date and cost of entire project: 2009-2010 $ 500,000

PI: Antonio Giordano

Source: PA Dept of Health:

Title: “Cancer Biomolecular Markers Research “

Date and cost of entire project: 2009- 2010 $ 2,000,000

PI: Antonio Giordano

Source: PA Dept of Labor and Industry:

Title: "Workforce Development Grant-Training Program”

Date and cost of entire project: 2010 $ 300,000

PI: Antonio Giordano

Source: PA Dept of Community and Economic Development

Title: “Lung Cancer Biotechnology Research and Training Project

Date and cost of entire project: 2008-2012 $ 1.4M

PI: Antonio Giordano

Source: Comune di Milano

Title: "Prolife: danni alla salute da inquinamento ambientale"

Date and cost of entire project: 2007-2010 Euro 300.000,00

PI: Francesco Cetta

Source: Ministero della Salute

Title: “Classificazione clinico-molecolare di pazienti con sindrome di Rett e ruolo di leptina e adiponectina nel fenotipo somatico”

Date and cost of entire project: 2010-2012 Euro 34.900,00

PI: Francesca Mari

Source: Commonwealth of PA

Title: “Redevelopment Assistance Capital Project”

Date and cost of entire project: 2010-2012 $ 3,000.000

(Included in State budget-pending formal award)

PI: Antonio Giordano

Source: IRSF (International Rett syndrome Foundation)

Title: “International Rett syndrome database”

Date and cost of entire project: 2010-2011 $ 5.000,00”

PI: Alessandra Renieri

Source: Regione Toscana

Title: “Percorso diagnostico-assistenziale per pazienti affetti dalla sindrome di Rett”

Date and cost of entire project: 2010-2011 Euro 10.000,00

PI: Alessandra Renieri

Source: Regione Toscana

Title: “Percorso diagnostico-terapeutico per pazienti affetti da Sindrome di Alport e nefropatie correlate”

Date and cost of entire project: 2010-2011 Euro 10.000,00

PI: Alessandra Renieri

Source: Regione Toscana

Title: “Ottimizzazione del percorso diagnostico-assistenziale per pazienti affetti da malattie genetiche rare”

Date and cost of entire project: 2010-2011 Euro 10.000,00

PI: Alessandra Renieri

Source: Telethon

Title: “Congenital Rett syndrome: cellular and mouse models for the study of FOXG1 impact on forebrain neurogenesis.”

Date and cost of entire project: 2009- 2014 Euro 293.100,00

PI: Alessandra Renieri

Source: Ministero della Salute

Title: “Induced pluripotent stem cells as in vitro models for the study of Rett syndrome pathogenesis and identification of therapeutic targets”

Date and cost of entire project: 2011-2014 Euro 164.120,00

PI: Alessandra Renieri

Source: AIRETT

Title: "Analisi dei geni HLA per individuare la suscettibilità genetica ai vaccini come componente della sindrome di Rett"

Date and cost of entire project: 2012-2014 Euro 25.000,00

Suorce: Telethon

Title: "Molecular bases and in vitro modeling of CDKL5 dependent infantile neurological disorders"

Date and cost of entire project: 2011-2014 Euro 108.400,00